| Summary: | Our continuing interest in anthraquinone had led the researchers to look at the synthesis of metal complex by reacting our major compound, nordamnacanthal with transition metal, Fe(II). Fe(II)-nordamnacanthal complex had been synthesized successfully via telescoping synthesis/one-pot reaction. The ligand and its metal complex were established by 1D and 2D nuclear magnetic resonance spectroscopy, UV-Visible, CHNS analyzer, gas chromatography mass spectrometry and infrared analysis. They were evaluated for their antimicrobial activity using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Fe(II)-nordamnacanthal complex showed stronger inhibition against Pseudomonas aeruginosa at the concentration of 450 µg/mL while Proteus vulgaris, Klebsiella pneumoniae and Salmonella pneumoniae at the concentration of 225 µg/mL compare to nordamnacanthal. In this work, the synthesized compound, Fe(II)-nordamnacanthal showed better antimicrobial activity compared to the ligand itself. © 2017, Malaysian Society of Analytical Sciences. All rights reserved.
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