Ursodeoxycholic acid protects cardiomyocytes against cobalt chloride induced hypoxia by regulating transcriptional mediator of cells stress hypoxia inducible factor 1α and p53 protein

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Ursodeoxycholic acid protects cardiomyocytes against cobalt chloride induced hypoxia by regulating transcriptional mediator of cells stress hypoxia inducible factor 1α and p53 protein

In hepatocytes, ursodeoxycholic acid (UDCA) activates cell signalling pathways such as p53, intracellular calcium ([Ca2+]i), and sphingosine-1-phosphate (S1P)-receptor via Gαi-coupled-receptor. Recently, UDCA has been shown to protect the heart against hypoxia-reoxygenation injury. However, it is no...

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Bibliographic Details
Published in:	Cell Biochemistry and Function
Main Author:	Mohamed A.S.; Hanafi N.I.; Sheikh Abdul Kadir S.H.; Md Noor J.; Abdul Hamid Hasani N.; Ab Rahim S.; Siran R.
Format:	Article
Language:	English
Published:	John Wiley and Sons Ltd 2017
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85031325768&doi=10.1002%2fcbf.3303&partnerID=40&md5=76edac7ed2f6e599351797d27545b12b

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