Biology-oriented drug synthesis (BIODS) of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl aryl ether derivatives, in vitro α-amylase inhibitory activity and in silico studies

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Biology-oriented drug synthesis (BIODS) of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl aryl ether derivatives, in vitro α-amylase inhibitory activity and in silico studies

A new library of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl aryl ether derivatives (1 −2 3) were synthesized and characterized by EI-MS and 1H NMR, and screened for their α-amylase inhibitory activity. Out of twenty-three derivatives, two molecules 19 (IC50 = 0.38 ± 0.82 µM) and 23 (IC50 = 1.66 ± 0....

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Bibliographic Details
Published in:	Bioorganic Chemistry
Main Author:	Taha M.; Imran S.; Ismail N.H.; Selvaraj M.; Rahim F.; Chigurupati S.; Ullah H.; Khan F.; Salar U.; Javid M.T.; Vijayabalan S.; Zaman K.; Khan K.M.
Format:	Article
Language:	English
Published:	Academic Press Inc. 2017
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85023632820&doi=10.1016%2fj.bioorg.2017.07.001&partnerID=40&md5=fc98ea30f6544b802e1948269a37dcef

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