Short asymmetric synthesis of a model monomeric unit for a/y peptide foldamers based on B-amino linked D-leucine - cis-γ-butyrolactone γ-acetic acid conjugate
This synthetic work reports a concise, asymmetric synthesis of B-amino-γ-butyrolactone acetic acid - D-leucine hybrid 1 which will serve as model starting template sub-unit for preparing A/γ foldameric oligopeptides containing unnatural γ-amino acid residues. The synthesis of cis-substituted 1 was s...
| Published in: | Organic Communications |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
ACG Publications
2017
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019732695&doi=10.25135%2facg.oc.13.16.12.474&partnerID=40&md5=699c96ac34c4f0af80ccd68e3e305706 |
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2-s2.0-85019732695 |
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2-s2.0-85019732695 Ali M.T.M.; Aliasak S.A.; Patrick A. Short asymmetric synthesis of a model monomeric unit for a/y peptide foldamers based on B-amino linked D-leucine - cis-γ-butyrolactone γ-acetic acid conjugate 2017 Organic Communications 10 2 10.25135/acg.oc.13.16.12.474 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019732695&doi=10.25135%2facg.oc.13.16.12.474&partnerID=40&md5=699c96ac34c4f0af80ccd68e3e305706 This synthetic work reports a concise, asymmetric synthesis of B-amino-γ-butyrolactone acetic acid - D-leucine hybrid 1 which will serve as model starting template sub-unit for preparing A/γ foldameric oligopeptides containing unnatural γ-amino acid residues. The synthesis of cis-substituted 1 was successfully achieved in six linear steps with very good stereoinduction. © 2017 ACG Publications. ACG Publications 13076175 English Article All Open Access; Gold Open Access |
| author |
Ali M.T.M.; Aliasak S.A.; Patrick A. |
| spellingShingle |
Ali M.T.M.; Aliasak S.A.; Patrick A. Short asymmetric synthesis of a model monomeric unit for a/y peptide foldamers based on B-amino linked D-leucine - cis-γ-butyrolactone γ-acetic acid conjugate |
| author_facet |
Ali M.T.M.; Aliasak S.A.; Patrick A. |
| author_sort |
Ali M.T.M.; Aliasak S.A.; Patrick A. |
| title |
Short asymmetric synthesis of a model monomeric unit for a/y peptide foldamers based on B-amino linked D-leucine - cis-γ-butyrolactone γ-acetic acid conjugate |
| title_short |
Short asymmetric synthesis of a model monomeric unit for a/y peptide foldamers based on B-amino linked D-leucine - cis-γ-butyrolactone γ-acetic acid conjugate |
| title_full |
Short asymmetric synthesis of a model monomeric unit for a/y peptide foldamers based on B-amino linked D-leucine - cis-γ-butyrolactone γ-acetic acid conjugate |
| title_fullStr |
Short asymmetric synthesis of a model monomeric unit for a/y peptide foldamers based on B-amino linked D-leucine - cis-γ-butyrolactone γ-acetic acid conjugate |
| title_full_unstemmed |
Short asymmetric synthesis of a model monomeric unit for a/y peptide foldamers based on B-amino linked D-leucine - cis-γ-butyrolactone γ-acetic acid conjugate |
| title_sort |
Short asymmetric synthesis of a model monomeric unit for a/y peptide foldamers based on B-amino linked D-leucine - cis-γ-butyrolactone γ-acetic acid conjugate |
| publishDate |
2017 |
| container_title |
Organic Communications |
| container_volume |
10 |
| container_issue |
2 |
| doi_str_mv |
10.25135/acg.oc.13.16.12.474 |
| url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019732695&doi=10.25135%2facg.oc.13.16.12.474&partnerID=40&md5=699c96ac34c4f0af80ccd68e3e305706 |
| description |
This synthetic work reports a concise, asymmetric synthesis of B-amino-γ-butyrolactone acetic acid - D-leucine hybrid 1 which will serve as model starting template sub-unit for preparing A/γ foldameric oligopeptides containing unnatural γ-amino acid residues. The synthesis of cis-substituted 1 was successfully achieved in six linear steps with very good stereoinduction. © 2017 ACG Publications. |
| publisher |
ACG Publications |
| issn |
13076175 |
| language |
English |
| format |
Article |
| accesstype |
All Open Access; Gold Open Access |
| record_format |
scopus |
| collection |
Scopus |
| _version_ |
1809677909234810880 |