Short asymmetric synthesis of a model monomeric unit for a/y peptide foldamers based on B-amino linked D-leucine - cis-γ-butyrolactone γ-acetic acid conjugate
This synthetic work reports a concise, asymmetric synthesis of B-amino-γ-butyrolactone acetic acid - D-leucine hybrid 1 which will serve as model starting template sub-unit for preparing A/γ foldameric oligopeptides containing unnatural γ-amino acid residues. The synthesis of cis-substituted 1 was s...
| Published in: | Organic Communications |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
ACG Publications
2017
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019732695&doi=10.25135%2facg.oc.13.16.12.474&partnerID=40&md5=699c96ac34c4f0af80ccd68e3e305706 |
| Summary: | This synthetic work reports a concise, asymmetric synthesis of B-amino-γ-butyrolactone acetic acid - D-leucine hybrid 1 which will serve as model starting template sub-unit for preparing A/γ foldameric oligopeptides containing unnatural γ-amino acid residues. The synthesis of cis-substituted 1 was successfully achieved in six linear steps with very good stereoinduction. © 2017 ACG Publications. |
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| ISSN: | 13076175 |
| DOI: | 10.25135/acg.oc.13.16.12.474 |