Selective dual cholinesterase inhibitors from Aconitum laeve

QR Code

Selective dual cholinesterase inhibitors from Aconitum laeve

New lycoctonine-type dual cholinesterase inhibitor, swatinine-C (1), along with three known norditerpenoid alkaloids, hohenackerine (2), aconorine (5) and lappaconitine (6) and two synthetically known but phytochemically new benzene derivatives, methyl 2-acetamidobenzoate (3) and methyl 4-[2-(methox...

Full description

Bibliographic Details
Published in:	Journal of Asian Natural Products Research
Main Author:	Ahmad H.; Ahmad S.; Shah S.A.A.; Khan H.U.; Khan F.A.; Ali M.; Latif A.; Shaheen F.; Ahmad M.
Format:	Note
Language:	English
Published:	Taylor and Francis Ltd. 2018
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018407862&doi=10.1080%2f10286020.2017.1319820&partnerID=40&md5=94928c13a9ddf72f387d434de1ff49e1

Similar Items

Norditerpenoid alkaloids of Delphinium denudatum as cholinesterase inhibitors
by: Ahmad H.; Ahmad S.; Ali M.; Latif A.; Shah S.A.A.; Naz H.; ur Rahman N.; Shaheen F.; Wadood A.; Khan H.U.; Ahmad M.
Published: (2018)

Synthesis and biological evaluation of substituted benzohydrazide Schiff base adduct as potential cholinesterase inhibitors
by: Zulfiqar A.; Khan I.U.; Nabi M.; Ullah H.; Iqbal N.; Zeb B.; Hussain A.; Khan D.; Rab A.; Junaid S.M.; Taha M.; Shah S.A.A.; Rahim F.
Published: (2024)

Synthesis and biological evaluation of substituted benzohydrazide Schiff base adduct as potential cholinesterase inhibitors
by: Zulfiqar, et al.
Published: (2024)

Multipotent Cholinesterase Inhibitors for the Treatment of Alzheimer’s Disease: Synthesis, Biological Analysis and Molecular Docking Study of Benzimidazole-Based Thiazole Derivatives
by: Hussain R.; Ullah H.; Rahim F.; Sarfraz M.; Taha M.; Iqbal R.; Rehman W.; Khan S.; Shah S.A.A.; Hyder S.; Alhomrani M.; Alamri A.S.; Abdulaziz O.; Abdelaziz M.A.
Published: (2022)

New Cholinesterase inhibitors based on 1,2,4-triazole bearing benzenesulfonohydrazide skeleton: Synthesis, in vitro and in silico studies
by: Othman M.S.; Naz H.; Rahim F.; Ullah H.; Hussain R.; Taha M.; Khan S.; Fareid M.A.; Aboelnaga S.M.; Altaleb A.T.; Iqbal R.; Adnan Ali Shah S.
Published: (2024)

Benzoxazole based thiazole hybrid analogs: Synthesis, in vitro cholinesterase inhibition, and molecular docking studies
by: Hussain R.; Rahim F.; Rehman W.; Adnan Ali Shah S.; Khan S.; Khan I.; Rasheed L.; Imran S.; Wadood A.; Abdellatif M.H.
Published: (2023)

Synthesis, in vitro biological analysis and molecular docking studies of new thiadiazole-based thiourea derivatives as dual inhibitors of a-amylase and a-glucosidase
by: Khan I.; Rehman W.; Rahim F.; Hussain R.; Khan S.; Rasheed L.; Alanazi A.S.; Hefnawy M.; Alanazi M.M.; Shah S.A.A.; Taha M.
Published: (2023)

Experimental and computational profiling of novel bis-Schiff base derivatives bearing α-naphthalene moiety as potential tyrosinase inhibitors
by: Shah T.A.; Alam A.; Zainab; Khan M.; Elhenawy A.A.; Ayaz M.; Ali M.; Latif A.; Shah S.A.A.; Ahmad M.
Published: (2025)

Discovery of Dual Inhibitors of Acetyl and Butrylcholinesterase and Antiproliferative Activity of 1,2,4-Triazole-3-thiol: Synthesis and In Silico Molecular Study
by: Siddiqui S.Z.; Arfan M.; Abbasi M.A.; Aziz-ur-Rehman; Shah S.A.A.; Ashraf M.; Hussain S.; Saleem R.S.Z.; Rafique R.; Khan K.M.
Published: (2020)

Characterisation of cholinesterase from kidney tissue of Asian seabass (Lates calcarifer) and its inhibition in presence of metal ions
by: Hayat N.M.; Ahmad S.A.; Shamaan N.A.; Jlah M.K.S.; Shukor M.Y.A.; Syed M.A.; Khalild A.; Khalil K.A.; Dahalan F.A.
Published: (2017)

5-Bromo-2-aryl benzimidazole derivatives as non-cytotoxic potential dual inhibitors of α-glucosidase and urease enzymes
by: Arshad T.; Khan K.M.; Rasool N.; Salar U.; Hussain S.; Asghar H.; Ashraf M.; Wadood A.; Riaz M.; Perveen S.; Taha M.; Ismail N.H.
Published: (2017)

Synthesis of 2,4-dihydroxyacetophenone derivatives as potent PDE-1 and -3 inhibitors: in vitro and in silico insights
by: Alam A.; Gul S.; Zainab; Khan M.; Elhenawy A.A.; Islam M.S.; Ali M.; Ali Shah S.A.; Latif A.; Ahmad M.
Published: (2024)

The β-carboline analogs as a potent inhibitor for Alzheimer's Disease, molecular docking and dynamics simulation study
by: Taha M.; Rahim F.; Khan A.A.; Adalat B.; Imran S.; Alshehri J.M.; Ahmad A.; Khan K.M.; Shah S.A.A.; Uddin N.
Published: (2023)

Molecular docking studies and in-vitro cholinesterase inhibitory activities of chemical constituents of Calophyllum gracilentum
by: Seruji N.M.U.; Jong V.Y.M.; Karunakaran T.; Zamakshshari N.H.; Mah S.H.; Gunter N.V.; Lizazman M.A.; Masayoshi A.
Published: (2024)

Design, synthesis of triazole-based scaffolds, N-(substitutedphenyl)-2-(5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazol-3-ylthiol)acetamides: As potential anti-cholinesterase agents for neurodegenerative diseases
by: Siddiqui S.Z.; Arfan M.; Abbasi M.A.; Aziz-ur-Rehman; Shah S.A.A.; Parveen R.; Ashraf M.; Solangi M.; Hussain S.; Khan K.M.
Published: (2023)

New biologically dynamic hybrid pharmacophore triazinoindole-based-thiadiazole as potent α-glucosidase inhibitors: In vitro and in silico study
by: Khan A.A.; Rahim F.; Taha M.; Rehman W.; Iqbal N.; Wadood A.; Ahmad N.; Shah S.A.A.; Ghoneim M.M.; Alshehri S.; Salahuddin M.; Khan K.M.
Published: (2022)

Synthesis of new 1,2-disubstituted benzimidazole analogs as potent inhibitors of β-Glucuronidase and in silico study
by: Taha M.; Ahmad Khan A.; Rahim F.; Imran S.; Salahuddin M.; Uddin N.; Mohammed Khan K.; Adnan Ali Shah S.; Zafar A.; Amiruddin Zakaria Z.
Published: (2022)

In Vitro and In Silico Investigation of Diterpenoid Alkaloids Isolated from Delphinium chitralense
by: Ahmad S.; Ahmad M.; Almehmadi M.; Shah S.A.A.; Khan F.A.; Khan N.M.; Khan A.; Zainab; Halawi M.; Ahmad H.
Published: (2022)

Synthesis and evaluation of unsymmetrical heterocyclic thioureas as potent β-glucuronidase inhibitors
by: Taha M.; Ismail N.H.; Jamil W.; Khan K.M.; Salar U.; Kashif S.M.; Rahim F.; Latif Y.
Published: (2015)

Dual-band bandpass ring filter
by: Khan Z.I.; Nordin S.A.; Ab Wahab N.; Zakaria N.Z.; Salleh M.K.Mohd.
Published: (2010)

Synthesis of benzimidazole derivatives as potent inhibitors for α-amylase and their molecular docking study in management of type-II diabetes
by: Hussain S.; Taha M.; Rahim F.; Hayat S.; Zaman K.; Iqbal N.; Selvaraj M.; Sajid M.; Bangesh M.A.; Khan F.; Khan K.M.; Uddin N.; Shah S.A.A.; Ali M.
Published: (2021)

Series-cascaded rings dual-band filter
by: Khan Z.I.; Salleh M.K.M.; Zakaria N.Z.
Published: (2010)

Dihydropyrimidones: As novel class of β-glucuronidase inhibitors
by: Ali F.; Khan K.M.; Salar U.; Iqbal S.; Taha M.; Ismail N.H.; Perveen S.; Wadood A.; Ghufran M.; Ali B.
Published: (2016)

Synthesis of diindolylmethane (DIM) bearing thiadiazole derivatives as a potent urease inhibitor
by: Taha M.; Rahim F.; Khan A.A.; Anouar E.H.; Ahmed N.; Shah S.A.A.; Ibrahim M.; Zakari Z.A.
Published: (2020)

Synthesis, biological evaluation and molecular docking study of benzimidazole derivatives as α-glucosidase inhibitors and anti-diabetes candidates
by: Hayat S.; Ullah H.; Rahim F.; Ullah I.; Taha M.; Iqbal N.; Khan F.; Khan M.S.; Shah S.A.A.; Wadood A.; Sajid M.; Abdalla A.N.
Published: (2023)

Synthesis of modified Schiff base appended 1,2,4-triazole hybrids scaffolds: elucidating the in vitro and in silico α-amylase and α-glucosidase inhibitors potential
by: Abbasi, et al.
Published: (2024)

Synthesis of Indole Based Sulfonamide Derivatives as potent inhibitors of α-glucosidase and α-amylase in management of type-II diabetes
by: Ullah W.; Rahim F.; Hayat S.; Ullah H.; Taha M.; Khan S.; Khaliq A.; Bibi S.; Gohar O.; Iqbal N.; Shah S.A.A.; Khan K.M.
Published: (2024)

Synthesis of new 2-{2,3-dihydro-1,4-benzodioxin-6-yl[(4‑methylphenyl) sulfonyl]amino}-N-(un/substituted-phenyl) acetamides as α-glucosidase and acetylcholinesterase inhibitors and their in silico study
by: Abbasi M.A.; Riaz S.; Aziz-Ur-rehman; Siddiqui S.Z.; Shah S.A.A.; Ashraf M.; Lodhi M.A.; Khan F.A.
Published: (2019)

Multi-selective reaction of azinane bearing oxadiazoles and substituted haloalkanes catalyzed by alkali metal hydride to access anti-enzymatic agents
by: Umair M.; Aziz-ur-Rehman; Abbasi M.A.; Siddiqui S.Z.; Iqbal J.; Rasool S.; Khan S.U.; Shah S.A.A.
Published: (2024)

Corruption, Funding Structure and Bank Lending of Dual Banking System
by: Ahmad N.F.G.; Saruchi S.A.; Muhammud F.S.
Published: (2024)

Synthesis, biological evaluation and molecular docking study of indazole based schiff base analogues as new anti-diabetic inhibitors
by: Taha M.; Gilani S.J.; Kazmi I.; Rahim F.; Adalat B.; Ullah H.; Nawaz F.; Wadood A.; Ali Z.; Shah S.A.A.; Khan K.M.
Published: (2024)

Semicarbazones, thiosemicarbazone, thiazole and oxazole analogues as monoamine oxidase inhibitors: Synthesis, characterization, biological evaluation, molecular docking, and kinetic studies
by: Qazi S.U.; Naz A.; Hameed A.; Osra F.A.; Jalil S.; Iqbal J.; Shah S.A.A.; Mirza A.Z.
Published: (2021)

Synthesis of chromen-4-one-oxadiazole substituted analogs as potent β-glucuronidase inhibitors
by: Taha M.; Rahim F.; Ali M.; Khan M.N.; Alqahtani M.A.; Bamarouf Y.A.; Gollapalli M.; Farooq R.K.; Ali Shah S.A.; Ahmed Q.U.; Zakaria Z.A.
Published: (2019)

Synthesis and Computational Exploration of Morpholine Bearing Halogenated Sulfonamides as Potential Tyrosinase Inhibitors
by: Abbasi M.A.; Raza H.; Aziz-ur-Rehman; Siddiqui S.Z.; Muhammad S.; Khan F.M.; Shah S.A.A.; Al-Sehemi A.G.; Kim S.J.
Published: (2023)

New acetylcholinesterase inhibitors isolated from Delphinium uncinatum
by: Gul N.; Ahmad S.; Ahmad H.; Aziz A.; Almehmadi M.; Amer Alsaiari A.; Allahyani M.; Zainab; Adnan Ali Shah S.; Ur Rahman N.; Ahmad M.
Published: (2023)

Biologically Potent Benzimidazole-Based-Substituted Benzaldehyde Derivatives as Potent Inhibitors for Alzheimer’s Disease along with Molecular Docking Study
by: Adalat B.; Rahim F.; Rehman W.; Ali Z.; Rasheed L.; Khan Y.; Farghaly T.A.; Shams S.; Taha M.; Wadood A.; Shah S.A.A.; Abdellatif M.H.
Published: (2023)

Dual-band bandpass filter with dumbbell shaped defective ground structure
by: Abdul Khalid M.F.; Ismail Khan Z.; Awang Z.; Pasya I.; Ab Wahab N.; Yassin I.M.
Published: (2017)

Development of bis-thiobarbiturates as successful urease inhibitors and their molecular modeling studies
by: Rahim F.; Ali M.; Ullah S.; Rashid U.; Ullah H.; Taha M.; Javed M.T.; Rehman W.; Khan A.A.; Abid O.U.R.; Bilal M.
Published: (2016)

Algerian Sonchus oleraceus L.: a comparison of different extraction solvent on phytochemical composition, antioxidant properties and anti-cholinesterase activity
by: Aissani F.; Grara N.; Bensouici C.; Bousbia A.; Ayed H.; Idris M.H.M.; Teh L.K.
Published: (2022)

Squeezed Light Generation Across Dual Octaves with Single-Mode Multichannel Waveguides
by: Julius R.; Khan Bin Zulkifpeli M.Z.; Ibrahim A.-B.M.A.
Published: (2023)