Chemical profiling and biological properties of Neolitsea kedahense Gamble essential oils

• Published in: Natural Product Research
• Main Author: Jani N.A.; Sirat H.M.; Ahmad F.; Mohamad Ali N.A.; Jamil M.
• Format: Article
• Language: English
• Published: Taylor and Francis Ltd. 2017
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85013769308&doi=10.1080%2f14786419.2017.1294172&partnerID=40&md5=0236a8b4731ba44f4bba902679581ff4

Hydrodistillation of the fresh stem and leaf of Neolitsea kedahense Gamble, collected from Gunung Jerai, Malaysia followed by the GC-FID and GC-MS analysis revealed the detection of a total of 47 constituents of which 28 (86.4%) from the stem and 31 (96.4%) constituents from the leaf. δ-Cadinene (17.4%), 1-epi-cubenol (11.8%), cyperotundone (9.0%), cis-cadin-4-en-7-ol (7.7%), τ-cadinol (7.1%) and α-cadinol (7.1%) were the principle constituents in the stem oil, whereas β-caryophyllene (18.9%), bicyclogermacrene (18.6%) and trans-muurola-4(14),5-diene (9.8%) were the major constituents in the leaf oil. Among the identified constituents, three constituents namely 7-epi-α-selinene, junenol and cis-cadin-4-en-7-ol have not been found previously from Neolitsea oils. The stem and leaf oils were screened for their α-glucosidase inhibitory and antibacterial activities. Both oils displayed potential α-glucosidase inhibitory activity, while the stem oil possessed weak antibacterial activity against Bacillus subtilis. © 2017 Informa UK Limited, trading as Taylor & Francis Group.