Thermoresponsive curcumin/DsiRNA nanoparticle gels for the treatment of diabetic wounds: Synthesis and drug release

Thermoresponsive curcumin/DsiRNA nanoparticle gels for the treatment of diabetic wounds: Synthesis and drug release

Aim: Chitosan (CS) has been extensively studied as drug delivery systems for wound healing. Results/methodology: CS nanoparticles were loaded with curcumin (Cur) and DsiRNA against prostaglandin transporter gene and they were incorporated into 20 and 25% w/v Pluronic F-127. The gels were later analy...

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Published in:Therapeutic Delivery
Main Author: Katas H.; Wen C.Y.; Siddique M.I.; Hussain Z.; Mohd Fadhil F.H.
Format: Article
Language:English
Published: Newlands Press Ltd 2017
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85011340333&doi=10.4155%2ftde-2016-0075&partnerID=40&md5=3515835b396825211d5fb1238d0ca5db
id 2-s2.0-85011340333
spelling 2-s2.0-85011340333
Katas H.; Wen C.Y.; Siddique M.I.; Hussain Z.; Mohd Fadhil F.H.
Thermoresponsive curcumin/DsiRNA nanoparticle gels for the treatment of diabetic wounds: Synthesis and drug release
2017
Therapeutic Delivery
8
3
10.4155/tde-2016-0075
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85011340333&doi=10.4155%2ftde-2016-0075&partnerID=40&md5=3515835b396825211d5fb1238d0ca5db
Aim: Chitosan (CS) has been extensively studied as drug delivery systems for wound healing. Results/methodology: CS nanoparticles were loaded with curcumin (Cur) and DsiRNA against prostaglandin transporter gene and they were incorporated into 20 and 25% w/v Pluronic F-127. The gels were later analyzed for their rheology, gelation temperature (Tgel), morphology, drug incorporation and in vitro drug release. The particle size was in the range of 231 ± 17-320 ± 20 nm, depending on CS concentration. The gels had Tgel of 23-28°C and exhibited sustained drug release with high accumulated amount of drugs over 48 h. Conclusion: A thermo-sensitive gel containing Cur/DsiRNA CS nanoparticles was successfully developed and has a great potential to be further developed. © 2017 Future Science Ltd.
Newlands Press Ltd
20415990
English
Article
author Katas H.; Wen C.Y.; Siddique M.I.; Hussain Z.; Mohd Fadhil F.H.
spellingShingle Katas H.; Wen C.Y.; Siddique M.I.; Hussain Z.; Mohd Fadhil F.H.
Thermoresponsive curcumin/DsiRNA nanoparticle gels for the treatment of diabetic wounds: Synthesis and drug release
author_facet Katas H.; Wen C.Y.; Siddique M.I.; Hussain Z.; Mohd Fadhil F.H.
author_sort Katas H.; Wen C.Y.; Siddique M.I.; Hussain Z.; Mohd Fadhil F.H.
title Thermoresponsive curcumin/DsiRNA nanoparticle gels for the treatment of diabetic wounds: Synthesis and drug release
title_short Thermoresponsive curcumin/DsiRNA nanoparticle gels for the treatment of diabetic wounds: Synthesis and drug release
title_full Thermoresponsive curcumin/DsiRNA nanoparticle gels for the treatment of diabetic wounds: Synthesis and drug release
title_fullStr Thermoresponsive curcumin/DsiRNA nanoparticle gels for the treatment of diabetic wounds: Synthesis and drug release
title_full_unstemmed Thermoresponsive curcumin/DsiRNA nanoparticle gels for the treatment of diabetic wounds: Synthesis and drug release
title_sort Thermoresponsive curcumin/DsiRNA nanoparticle gels for the treatment of diabetic wounds: Synthesis and drug release
publishDate 2017
container_title Therapeutic Delivery
container_volume 8
container_issue 3
doi_str_mv 10.4155/tde-2016-0075
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85011340333&doi=10.4155%2ftde-2016-0075&partnerID=40&md5=3515835b396825211d5fb1238d0ca5db
description Aim: Chitosan (CS) has been extensively studied as drug delivery systems for wound healing. Results/methodology: CS nanoparticles were loaded with curcumin (Cur) and DsiRNA against prostaglandin transporter gene and they were incorporated into 20 and 25% w/v Pluronic F-127. The gels were later analyzed for their rheology, gelation temperature (Tgel), morphology, drug incorporation and in vitro drug release. The particle size was in the range of 231 ± 17-320 ± 20 nm, depending on CS concentration. The gels had Tgel of 23-28°C and exhibited sustained drug release with high accumulated amount of drugs over 48 h. Conclusion: A thermo-sensitive gel containing Cur/DsiRNA CS nanoparticles was successfully developed and has a great potential to be further developed. © 2017 Future Science Ltd.
publisher Newlands Press Ltd
issn 20415990
language English
format Article
accesstype
record_format scopus
collection Scopus
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