Thermoresponsive curcumin/DsiRNA nanoparticle gels for the treatment of diabetic wounds: Synthesis and drug release

• Published in: Therapeutic Delivery
• Main Author: Katas H.; Wen C.Y.; Siddique M.I.; Hussain Z.; Mohd Fadhil F.H.
• Format: Article
• Language: English
• Published: Newlands Press Ltd 2017
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85011340333&doi=10.4155%2ftde-2016-0075&partnerID=40&md5=3515835b396825211d5fb1238d0ca5db
• ISSN: 20415990
• DOI: 10.4155/tde-2016-0075

Aim: Chitosan (CS) has been extensively studied as drug delivery systems for wound healing. Results/methodology: CS nanoparticles were loaded with curcumin (Cur) and DsiRNA against prostaglandin transporter gene and they were incorporated into 20 and 25% w/v Pluronic F-127. The gels were later analyzed for their rheology, gelation temperature (Tgel), morphology, drug incorporation and in vitro drug release. The particle size was in the range of 231 ± 17-320 ± 20 nm, depending on CS concentration. The gels had Tgel of 23-28°C and exhibited sustained drug release with high accumulated amount of drugs over 48 h. Conclusion: A thermo-sensitive gel containing Cur/DsiRNA CS nanoparticles was successfully developed and has a great potential to be further developed. © 2017 Future Science Ltd.