Synthesis, in vitro β-glucuronidase inhibitory activity and in silico studies of novel (E)-4-Aryl-2-(2-(pyren-1-ylmethylene)hydrazinyl)thiazoles

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Synthesis, in vitro β-glucuronidase inhibitory activity and in silico studies of novel (E)-4-Aryl-2-(2-(pyren-1-ylmethylene)hydrazinyl)thiazoles

Current research is based on the synthesis of novel (E)-4-aryl-2-(2-(pyren-1-ylmethylene)hydrazinyl)thiazole derivatives (3–15) by adopting two steps route. First step was the condensation between the pyrene-1-carbaldehyde (1) with the thiosemicarbazide to afford pyrene-1-thiosemicarbazone intermedi...

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Bibliographic Details
Published in:	Bioorganic Chemistry
Main Author:	Salar U.; Khan K.M.; Syed S.; Taha M.; Ali F.; Ismail N.H.; Perveen S.; Wadood A.; Ghufran M.
Format:	Article
Language:	English
Published:	Academic Press Inc. 2017
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85008692996&doi=10.1016%2fj.bioorg.2016.12.011&partnerID=40&md5=42292fa227465765af9d2f111fa1fbb6

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