Synthesis and molecular modelling studies of phenyl linked oxadiazole-phenylhydrazone hybrids as potent antileishmanial agents

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Synthesis and molecular modelling studies of phenyl linked oxadiazole-phenylhydrazone hybrids as potent antileishmanial agents

Molecular hybridization yielded phenyl linked oxadiazole-benzohydrazones hybrids 6–35 and were evaluated for their antileishmanial potentials. Compound 10, a 3,4-dihydroxy analog with IC50value of 0.95 ± 0.01 μM, was found to be the most potent antileishmanial agent (7 times more active) than the st...

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Bibliographic Details
Published in:	European Journal of Medicinal Chemistry
Main Author:	Taha M.; Ismail N.H.; Imran S.; Anouar E.H.; Selvaraj M.; Jamil W.; Ali M.; Kashif S.M.; Rahim F.; Khan K.M.; Adenan M.I.
Format:	Article
Language:	English
Published:	Elsevier Masson SAS 2017
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85006802382&doi=10.1016%2fj.ejmech.2016.12.019&partnerID=40&md5=715f0059120195ba1e75dba8e4ebe2d3

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