Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: A review of new trends and state-of-the-art

Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: A review of new trends and state-of-the-art

Wound healing is a multifarious and vibrant process of replacing devitalized and damaged cellular structures, leading to restoration of the skin's barrier function, re-establishment of tissue integrity, and maintenance of the internal homeostasis. Curcumin (CUR) and its analogs have gained wide...

Full description

Bibliographic Details
Published in:Colloids and Surfaces B: Biointerfaces
Main Author: Hussain Z.; Thu H.E.; Ng S.-F.; Khan S.; Katas H.
Format: Review
Language:English
Published: Elsevier B.V. 2017
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85000997466&doi=10.1016%2fj.colsurfb.2016.11.036&partnerID=40&md5=a7662c1614dafac9a18c6851bb33d729
id 2-s2.0-85000997466
spelling 2-s2.0-85000997466
Hussain Z.; Thu H.E.; Ng S.-F.; Khan S.; Katas H.
Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: A review of new trends and state-of-the-art
2017
Colloids and Surfaces B: Biointerfaces
150

10.1016/j.colsurfb.2016.11.036
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85000997466&doi=10.1016%2fj.colsurfb.2016.11.036&partnerID=40&md5=a7662c1614dafac9a18c6851bb33d729
Wound healing is a multifarious and vibrant process of replacing devitalized and damaged cellular structures, leading to restoration of the skin's barrier function, re-establishment of tissue integrity, and maintenance of the internal homeostasis. Curcumin (CUR) and its analogs have gained widespread recognition due to their remarkable anti-inflammatory, anti-infective, anticancer, immunomodulatory, antioxidant, and wound healing activities. However, their pharmaceutical significance is limited due to inherent hydrophobic nature, poor water solubility, low bioavailability, chemical instability, rapid metabolism and short half-life. Owing to their pharmaceutical limitations, newer strategies have been attempted in recent years aiming to mitigate problems related to the effective delivery of curcumanoids and to improve their wound healing potential. These advanced strategies include nanovesicles, polymeric micelles, conventional liposomes and hyalurosomes, nanocomposite hydrogels, electrospun nanofibers, nanohybrid scaffolds, nanoconjugates, nanostructured lipid carriers (NLCs), nanoemulsion, nanodispersion, and polymeric nanoparticles (NPs). The superior wound healing activities achieved after nanoencapsulation of the CUR are attributed to its target-specific delivery, longer retention at the target site, avoiding premature degradation of the encapsulated cargo and the therapeutic superiority of the advanced delivery systems over the conventional delivery. We have critically reviewed the literature and summarize the convincing evidence which explore the pharmaceutical significance and therapeutic feasibility of the advanced delivery systems in improving wound healing activities of the CUR and its analogs. © 2016 Elsevier B.V.
Elsevier B.V.
09277765
English
Review
author Hussain Z.; Thu H.E.; Ng S.-F.; Khan S.; Katas H.
spellingShingle Hussain Z.; Thu H.E.; Ng S.-F.; Khan S.; Katas H.
Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: A review of new trends and state-of-the-art
author_facet Hussain Z.; Thu H.E.; Ng S.-F.; Khan S.; Katas H.
author_sort Hussain Z.; Thu H.E.; Ng S.-F.; Khan S.; Katas H.
title Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: A review of new trends and state-of-the-art
title_short Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: A review of new trends and state-of-the-art
title_full Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: A review of new trends and state-of-the-art
title_fullStr Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: A review of new trends and state-of-the-art
title_full_unstemmed Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: A review of new trends and state-of-the-art
title_sort Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: A review of new trends and state-of-the-art
publishDate 2017
container_title Colloids and Surfaces B: Biointerfaces
container_volume 150
container_issue
doi_str_mv 10.1016/j.colsurfb.2016.11.036
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85000997466&doi=10.1016%2fj.colsurfb.2016.11.036&partnerID=40&md5=a7662c1614dafac9a18c6851bb33d729
description Wound healing is a multifarious and vibrant process of replacing devitalized and damaged cellular structures, leading to restoration of the skin's barrier function, re-establishment of tissue integrity, and maintenance of the internal homeostasis. Curcumin (CUR) and its analogs have gained widespread recognition due to their remarkable anti-inflammatory, anti-infective, anticancer, immunomodulatory, antioxidant, and wound healing activities. However, their pharmaceutical significance is limited due to inherent hydrophobic nature, poor water solubility, low bioavailability, chemical instability, rapid metabolism and short half-life. Owing to their pharmaceutical limitations, newer strategies have been attempted in recent years aiming to mitigate problems related to the effective delivery of curcumanoids and to improve their wound healing potential. These advanced strategies include nanovesicles, polymeric micelles, conventional liposomes and hyalurosomes, nanocomposite hydrogels, electrospun nanofibers, nanohybrid scaffolds, nanoconjugates, nanostructured lipid carriers (NLCs), nanoemulsion, nanodispersion, and polymeric nanoparticles (NPs). The superior wound healing activities achieved after nanoencapsulation of the CUR are attributed to its target-specific delivery, longer retention at the target site, avoiding premature degradation of the encapsulated cargo and the therapeutic superiority of the advanced delivery systems over the conventional delivery. We have critically reviewed the literature and summarize the convincing evidence which explore the pharmaceutical significance and therapeutic feasibility of the advanced delivery systems in improving wound healing activities of the CUR and its analogs. © 2016 Elsevier B.V.
publisher Elsevier B.V.
issn 09277765
language English
format Review
accesstype
record_format scopus
collection Scopus
_version_ 1814778508682985472

Similar Items