Anti-cancer potential of benzophenone-bis-Schiff bases on human pancreatic cancer cell line

• Published in: Journal of the Chemical Society of Pakistan
• Main Author: Khan K.M.; Rasheed H.; Fatima B.; Hayat M.; Rahim F.; Ullah H.; Hameed A.; Taha M.; Tahir A.; Perveen S.
• Format: Article
• Language: English
• Published: Chemical Society of Pakistan 2016
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84995460997&partnerID=40&md5=57fae9b20ad7f8219576edc21143ce65

Synthetic benzophenone-bis-Schiff bases (1-17) were evaluated for PC3 cell line inhibition. Most of the compounds showed cytotoxic effects but compounds 4, 8, 14, 16, and 17 were found to be potent. The growth inhibition of PC3 cells was in a concentration-dependent manner when treated with compounds 4, 8, 14, 16 and 17 (Figure-2) after 24 h exposure time. The IC50 values of all five most active compounds were calculated as 4 (IC50 = 24 ± 1.4 μM), 8 (IC50 = 29 ± 1.3 μM), 14 (IC50 = 66 ± 2.8 μM), 16 (IC50 = 28 ± 1.4 μM) and 17 (IC50 = 18 ± 2.8 μM) when compared with standard cisplatin (IC50 = 20 ± 1.1 μM). This study has identified potent anticancer agents. © 2016, Chemical Society of Pakistan. All rights reserved.