Open-label study of absorption and clearance of 1% voriconazole eye drops
Twenty participants undergoing elective cataract surgery received 1% voriconazole eye drops (1 drop per eye) either 20, 40, 60, or 80 min before surgery. Median voriconazole concentrations of 1.9 to 3.2 mg/liter in aqueous humor samples were attained over the first 80 min, which were higher than in...
| Published in: | Antimicrobial Agents and Chemotherapy |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2016
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84994525872&doi=10.1128%2fAAC.00683-16&partnerID=40&md5=7f7824bbc078c43461e06862abdf1401 |
| Summary: | Twenty participants undergoing elective cataract surgery received 1% voriconazole eye drops (1 drop per eye) either 20, 40, 60, or 80 min before surgery. Median voriconazole concentrations of 1.9 to 3.2 mg/liter in aqueous humor samples were attained over the first 80 min, which were higher than in vitro MIC90 values for typical fungi that cause keratitis. Copyright © 2016, American Society for Microbiology. All Rights Reserved. |
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| ISSN: | 664804 |
| DOI: | 10.1128/AAC.00683-16 |