Identification of novel acetylcholinesterase inhibitors: Indolopyrazoline derivatives and molecular docking studies

Identification of novel acetylcholinesterase inhibitors: Indolopyrazoline derivatives and molecular docking studies

The synthesis of novel indolopyrazoline derivatives (P1-P4 and Q1-Q4) has been characterized and evaluated as potential anti-Alzheimer agents through in vitro Acetylcholinesterase (AChE) inhibition and radical scavenging activity (antioxidant) studies. Specifically, Q3 shows AChE inhibition (IC50: 0...

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Bibliographic Details
Published in:Bioorganic Chemistry
Main Author: Chigurupati S.; Selvaraj M.; Mani V.; Selvarajan K.K.; Mohammad J.I.; Kaveti B.; Bera H.; Palanimuthu V.R.; Teh L.K.; Salleh M.Z.
Format: Article
Language:English
Published: Academic Press Inc. 2016
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988957420&doi=10.1016%2fj.bioorg.2016.05.002&partnerID=40&md5=888f8a3acf498f30dda9c78f34d76321

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https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988957420&doi=10.1016%2fj.bioorg.2016.05.002&partnerID=40&md5=888f8a3acf498f30dda9c78f34d76321

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