Chemical constituents and bioactivities from the leaves of Beilschmiedia glabra Kosterm (Lauraceae); [Beilschmiedia glabra yapraklarıından izole edilen kimyasal bileşenlerin biyolojik etkinleri]
Two butanolides, subamolide D (1) and subamolide E (2), along with β-sitosterol (3), β-sitostenone (4), lupeol (5), taraxerol (6), and 24-methylenelanosta-7,9(11)-diene-3β,15α-diol (7) were isolated from the leaves of Beilschmiedia glabra. The structures of the isolated compounds were elucidated by...
| Published in: | Marmara Pharmaceutical Journal |
|---|---|
| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Marmara University
2016
|
| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988556968&doi=10.12991%2fmpj.20162079371&partnerID=40&md5=d3b4e6639228cf09665992d03c804cda |
| Summary: | Two butanolides, subamolide D (1) and subamolide E (2), along with β-sitosterol (3), β-sitostenone (4), lupeol (5), taraxerol (6), and 24-methylenelanosta-7,9(11)-diene-3β,15α-diol (7) were isolated from the leaves of Beilschmiedia glabra. The structures of the isolated compounds were elucidated by extensive spectroscopic data analysis and comparison with respective literature data. The compounds were tested for DPPH• radical scavenging, antimicrobial, acetylcholinesterase and lipoxygenase inhibitory activities. Compounds 1 and 2 displayed the strongest lipoxygenase assay with an IC50 value of 5.1 and 5.5 μM, respectively. All compounds showed weak activity on DPPH• radical-scavenging, antimicrobial, and acetylcholinesterase inhibition assays. © Marmara University. All rights reserved. |
|---|---|
| ISSN: | 13090801 |
| DOI: | 10.12991/mpj.20162079371 |