Combinatorial cytotoxic effects of damnacanthal and doxorubicin against human breast cancer MCF-7 cells in vitro

Despite progressive research being done on drug therapy to treat breast cancer, the number of patients succumbing to the disease is still a major issue. Combinatorial treatment using different drugs and herbs to treat cancer patients is of major interest in scientists nowadays. Doxorubicin is one of...

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Published in:Molecules
Main Author: Aziz M.Y.A.; Abu N.; Yeap S.K.; Ho W.Y.; Omar A.R.; Ismail N.H.; Ahmad S.; Pirozyan M.R.; Akhtar N.M.; Alitheen N.B.
Format: Article
Language:English
Published: MDPI AG 2016
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84987923868&doi=10.3390%2fmolecules21091228&partnerID=40&md5=5caa5d1589e5f6e4bf71f2e8719d7dbf
id 2-s2.0-84987923868
spelling 2-s2.0-84987923868
Aziz M.Y.A.; Abu N.; Yeap S.K.; Ho W.Y.; Omar A.R.; Ismail N.H.; Ahmad S.; Pirozyan M.R.; Akhtar N.M.; Alitheen N.B.
Combinatorial cytotoxic effects of damnacanthal and doxorubicin against human breast cancer MCF-7 cells in vitro
2016
Molecules
21
9
10.3390/molecules21091228
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84987923868&doi=10.3390%2fmolecules21091228&partnerID=40&md5=5caa5d1589e5f6e4bf71f2e8719d7dbf
Despite progressive research being done on drug therapy to treat breast cancer, the number of patients succumbing to the disease is still a major issue. Combinatorial treatment using different drugs and herbs to treat cancer patients is of major interest in scientists nowadays. Doxorubicin is one of the most used drugs to treat breast cancer patients. The combination of doxorubicin to other drugs such as tamoxifen has been reported. Nevertheless, the combination of doxorubicin with a natural product-derived agent has not been studied yet. Morinda citrifolia has always been sought out for its remarkable remedies. Damnacanthal, an anthraquinone that can be extracted from the roots of Morinda citrifolia is a promising compound that possesses a variety of biological properties. This study aimed to study the therapeutic effects of damnacanthal in combination with doxorubicin in breast cancer cells. Collectively, the combination of both these molecules enhanced the efficacy of induced cell death in MCF-7 as evidenced by the MTT assay, cell cycle, annexin V and expression of apoptosis-related genes and proteins. The effectiveness of doxorubicin as an anti-cancer drug was increased upon addition of damnacanthal. These results could provide a promising approach to treat breast cancer patients. © 2016 by the authors; licensee MDPI, Basel, Switzerland.
MDPI AG
14203049
English
Article
All Open Access; Gold Open Access
author Aziz M.Y.A.; Abu N.; Yeap S.K.; Ho W.Y.; Omar A.R.; Ismail N.H.; Ahmad S.; Pirozyan M.R.; Akhtar N.M.; Alitheen N.B.
spellingShingle Aziz M.Y.A.; Abu N.; Yeap S.K.; Ho W.Y.; Omar A.R.; Ismail N.H.; Ahmad S.; Pirozyan M.R.; Akhtar N.M.; Alitheen N.B.
Combinatorial cytotoxic effects of damnacanthal and doxorubicin against human breast cancer MCF-7 cells in vitro
author_facet Aziz M.Y.A.; Abu N.; Yeap S.K.; Ho W.Y.; Omar A.R.; Ismail N.H.; Ahmad S.; Pirozyan M.R.; Akhtar N.M.; Alitheen N.B.
author_sort Aziz M.Y.A.; Abu N.; Yeap S.K.; Ho W.Y.; Omar A.R.; Ismail N.H.; Ahmad S.; Pirozyan M.R.; Akhtar N.M.; Alitheen N.B.
title Combinatorial cytotoxic effects of damnacanthal and doxorubicin against human breast cancer MCF-7 cells in vitro
title_short Combinatorial cytotoxic effects of damnacanthal and doxorubicin against human breast cancer MCF-7 cells in vitro
title_full Combinatorial cytotoxic effects of damnacanthal and doxorubicin against human breast cancer MCF-7 cells in vitro
title_fullStr Combinatorial cytotoxic effects of damnacanthal and doxorubicin against human breast cancer MCF-7 cells in vitro
title_full_unstemmed Combinatorial cytotoxic effects of damnacanthal and doxorubicin against human breast cancer MCF-7 cells in vitro
title_sort Combinatorial cytotoxic effects of damnacanthal and doxorubicin against human breast cancer MCF-7 cells in vitro
publishDate 2016
container_title Molecules
container_volume 21
container_issue 9
doi_str_mv 10.3390/molecules21091228
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-84987923868&doi=10.3390%2fmolecules21091228&partnerID=40&md5=5caa5d1589e5f6e4bf71f2e8719d7dbf
description Despite progressive research being done on drug therapy to treat breast cancer, the number of patients succumbing to the disease is still a major issue. Combinatorial treatment using different drugs and herbs to treat cancer patients is of major interest in scientists nowadays. Doxorubicin is one of the most used drugs to treat breast cancer patients. The combination of doxorubicin to other drugs such as tamoxifen has been reported. Nevertheless, the combination of doxorubicin with a natural product-derived agent has not been studied yet. Morinda citrifolia has always been sought out for its remarkable remedies. Damnacanthal, an anthraquinone that can be extracted from the roots of Morinda citrifolia is a promising compound that possesses a variety of biological properties. This study aimed to study the therapeutic effects of damnacanthal in combination with doxorubicin in breast cancer cells. Collectively, the combination of both these molecules enhanced the efficacy of induced cell death in MCF-7 as evidenced by the MTT assay, cell cycle, annexin V and expression of apoptosis-related genes and proteins. The effectiveness of doxorubicin as an anti-cancer drug was increased upon addition of damnacanthal. These results could provide a promising approach to treat breast cancer patients. © 2016 by the authors; licensee MDPI, Basel, Switzerland.
publisher MDPI AG
issn 14203049
language English
format Article
accesstype All Open Access; Gold Open Access
record_format scopus
collection Scopus
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