Synthesis of novel bisindolylmethanes: New carbonic anhydrase II inhibitors, docking, and 3D pharmacophore studies

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Synthesis of novel bisindolylmethanes: New carbonic anhydrase II inhibitors, docking, and 3D pharmacophore studies

In this study, 45 bisindolylmethanes having sulfonamide moiety had been synthesized through 3 steps. In vitro assay for inhibition of carbonic anhydrase showed that some of the compounds having sulfonamide moiety are capable of inhibiting carbonic anhydrase II. Bisindoles having halogens at fifth po...

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Bibliographic Details
Published in:	Bioorganic Chemistry
Main Author:	Imran S.; Taha M.; Ismail N.H.; Fayyaz S.; Khan K.M.; Choudhary M.I.
Format:	Article
Language:	English
Published:	Academic Press Inc. 2016
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84979563818&doi=10.1016%2fj.bioorg.2016.07.011&partnerID=40&md5=e30623e4726c2e7c8c99ea07043065e1

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