Synthesis, β-glucuronidase inhibition and molecular docking studies of hybrid bisindole-thiosemicarbazides analogs

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Synthesis, β-glucuronidase inhibition and molecular docking studies of hybrid bisindole-thiosemicarbazides analogs

Hybrid bisindole-thiosemicarbazides analogs (1–18) were synthesized and screened for β-glucuronidase activity. All compounds showed varied degree of β-glucuronidase inhibitory potential when compared with standard D-saccharic acid 1,4-lactone (IC50 = 48.4 ± 1.25 μM). Compounds 4, 7, 9, 6, 5, 12, 17...

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Bibliographic Details
Published in:	Bioorganic Chemistry
Main Author:	Taha M.; Ismail N.H.; Imran S.; Rahim F.; Wadood A.; Khan H.; Ullah H.; Salar U.; Khan K.M.
Format:	Article
Language:	English
Published:	Academic Press Inc. 2016
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84978872852&doi=10.1016%2fj.bioorg.2016.07.008&partnerID=40&md5=f8a4038427a07f754f92a8c5f386c6af

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