Synthesis and biological evaluation of novel N-arylidenequinoline-3-carbohydrazides as potent β-glucuronidase inhibitors

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Synthesis and biological evaluation of novel N-arylidenequinoline-3-carbohydrazides as potent β-glucuronidase inhibitors

Thirty N-arylidenequinoline-3-carbohydrazides (1–30) have been synthesized and evaluated against β-glucuronidase inhibitory potential. Twenty four analogs showed outstanding β-glucuronidase activity having IC50values ranging between 2.11 ± 0.05 and 46.14 ± 0.95 than standard D-saccharic acid 1,4 lac...

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Bibliographic Details
Published in:	Bioorganic and Medicinal Chemistry
Main Author:	Taha M.; Sultan S.; Nuzar H.A.; Rahim F.; Imran S.; Ismail N.H.; Naz H.; Ullah H.
Format:	Article
Language:	English
Published:	Elsevier Ltd 2016
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84978286017&doi=10.1016%2fj.bmc.2016.06.008&partnerID=40&md5=03ca04d172bfd0b30ab2122b709d35e2

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