Novel Armed Pyrazolobenzothiazine Derivatives: Synthesis, X-Ray Crystal Structure and POM analyses of Biological Activity Against Drug Resistant Clinical Isolate of Staphylococcus aureus

Novel Armed Pyrazolobenzothiazine Derivatives: Synthesis, X-Ray Crystal Structure and POM analyses of Biological Activity Against Drug Resistant Clinical Isolate of Staphylococcus aureus

Novel structural hybrids of pyrazolobenzothiazine and triazole ring systems have been prepared to observe a synergistic effect of the two ring systems. The methodology involves condensation of pyrazolobenzothiazine rings with methyl chloroacetate, followed by hydrazide formation. The hydrazides were...

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Published in:Pharmaceutical Chemistry Journal
Main Author: Sajid Z.; Ahmad M.; Aslam S.; Ashfaq U.A.; Zahoor A.F.; Saddique F.A.; Parvez M.; Hameed A.; Sultan S.; Zgou H.; Hadda T.B.
Format: Article
Language:English
Published: Springer New York LLC 2016
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84978039210&doi=10.1007%2fs11094-016-1417-y&partnerID=40&md5=05562b99750bceb52c0d1899413d8241
id 2-s2.0-84978039210
spelling 2-s2.0-84978039210
Sajid Z.; Ahmad M.; Aslam S.; Ashfaq U.A.; Zahoor A.F.; Saddique F.A.; Parvez M.; Hameed A.; Sultan S.; Zgou H.; Hadda T.B.
Novel Armed Pyrazolobenzothiazine Derivatives: Synthesis, X-Ray Crystal Structure and POM analyses of Biological Activity Against Drug Resistant Clinical Isolate of Staphylococcus aureus
2016
Pharmaceutical Chemistry Journal
50
3
10.1007/s11094-016-1417-y
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84978039210&doi=10.1007%2fs11094-016-1417-y&partnerID=40&md5=05562b99750bceb52c0d1899413d8241
Novel structural hybrids of pyrazolobenzothiazine and triazole ring systems have been prepared to observe a synergistic effect of the two ring systems. The methodology involves condensation of pyrazolobenzothiazine rings with methyl chloroacetate, followed by hydrazide formation. The hydrazides were converted to triazoles through the formation of intermediate potassium salts of dithiocarbazate. The final compounds as well as intermediates were screened for their antibacterial activity against a multidrug resistant strain of Staphylococcus aureus. It was interesting to observe that dithiocarbazates (7a, 7b) and target triazoles (8a, 8b) exhibited antibacterial activity. © 2016, Springer Science+Business Media New York.
Springer New York LLC
0091150X
English
Article
author Sajid Z.; Ahmad M.; Aslam S.; Ashfaq U.A.; Zahoor A.F.; Saddique F.A.; Parvez M.; Hameed A.; Sultan S.; Zgou H.; Hadda T.B.
spellingShingle Sajid Z.; Ahmad M.; Aslam S.; Ashfaq U.A.; Zahoor A.F.; Saddique F.A.; Parvez M.; Hameed A.; Sultan S.; Zgou H.; Hadda T.B.
Novel Armed Pyrazolobenzothiazine Derivatives: Synthesis, X-Ray Crystal Structure and POM analyses of Biological Activity Against Drug Resistant Clinical Isolate of Staphylococcus aureus
author_facet Sajid Z.; Ahmad M.; Aslam S.; Ashfaq U.A.; Zahoor A.F.; Saddique F.A.; Parvez M.; Hameed A.; Sultan S.; Zgou H.; Hadda T.B.
author_sort Sajid Z.; Ahmad M.; Aslam S.; Ashfaq U.A.; Zahoor A.F.; Saddique F.A.; Parvez M.; Hameed A.; Sultan S.; Zgou H.; Hadda T.B.
title Novel Armed Pyrazolobenzothiazine Derivatives: Synthesis, X-Ray Crystal Structure and POM analyses of Biological Activity Against Drug Resistant Clinical Isolate of Staphylococcus aureus
title_short Novel Armed Pyrazolobenzothiazine Derivatives: Synthesis, X-Ray Crystal Structure and POM analyses of Biological Activity Against Drug Resistant Clinical Isolate of Staphylococcus aureus
title_full Novel Armed Pyrazolobenzothiazine Derivatives: Synthesis, X-Ray Crystal Structure and POM analyses of Biological Activity Against Drug Resistant Clinical Isolate of Staphylococcus aureus
title_fullStr Novel Armed Pyrazolobenzothiazine Derivatives: Synthesis, X-Ray Crystal Structure and POM analyses of Biological Activity Against Drug Resistant Clinical Isolate of Staphylococcus aureus
title_full_unstemmed Novel Armed Pyrazolobenzothiazine Derivatives: Synthesis, X-Ray Crystal Structure and POM analyses of Biological Activity Against Drug Resistant Clinical Isolate of Staphylococcus aureus
title_sort Novel Armed Pyrazolobenzothiazine Derivatives: Synthesis, X-Ray Crystal Structure and POM analyses of Biological Activity Against Drug Resistant Clinical Isolate of Staphylococcus aureus
publishDate 2016
container_title Pharmaceutical Chemistry Journal
container_volume 50
container_issue 3
doi_str_mv 10.1007/s11094-016-1417-y
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-84978039210&doi=10.1007%2fs11094-016-1417-y&partnerID=40&md5=05562b99750bceb52c0d1899413d8241
description Novel structural hybrids of pyrazolobenzothiazine and triazole ring systems have been prepared to observe a synergistic effect of the two ring systems. The methodology involves condensation of pyrazolobenzothiazine rings with methyl chloroacetate, followed by hydrazide formation. The hydrazides were converted to triazoles through the formation of intermediate potassium salts of dithiocarbazate. The final compounds as well as intermediates were screened for their antibacterial activity against a multidrug resistant strain of Staphylococcus aureus. It was interesting to observe that dithiocarbazates (7a, 7b) and target triazoles (8a, 8b) exhibited antibacterial activity. © 2016, Springer Science+Business Media New York.
publisher Springer New York LLC
issn 0091150X
language English
format Article
accesstype
record_format scopus
collection Scopus
_version_ 1823296164497195008

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