Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance

Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance

While age-related insulin resistance and hyperinsulinemia are usually considered to be secondary to changes in muscle, the liver also plays a key role in whole-body insulin handling and its role in age-related changes in insulin homeostasis is largely unknown. Here, we show that patent pores called...

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Bibliographic Details
Published in:Aging Cell
Main Author: Mohamad M.; Mitchell S.J.; Wu L.E.; White M.Y.; Cordwell S.J.; Mach J.; Solon-Biet S.M.; Boyer D.; Nines D.; Das A.; Catherine Li S.-Y.; Warren A.; Hilmer S.N.; Fraser R.; Sinclair D.A.; Simpson S.J.; de Cabo R.; Le Couteur D.G.; Cogger V.C.
Format: Article
Language:English
Published: Blackwell Publishing Ltd 2016
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84977636917&doi=10.1111%2facel.12481&partnerID=40&md5=b64ffcfebcd96359be9ec2ce8400a7e4

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