Syntheses of new 3-thiazolyl coumarin derivatives, in vitro α-glucosidase inhibitory activity, and molecular modeling studies

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Syntheses of new 3-thiazolyl coumarin derivatives, in vitro α-glucosidase inhibitory activity, and molecular modeling studies

3-Thiazolylcoumarin derivatives 1–14 were synthesized via one-pot two step reactions, and screened for in vitro α-glucosidase inhibitory activity. All compounds showed inhibitory activity in the range of IC50 = 0.12 ± 0.01–16.20 ± 0.23 μM as compared to standard acarbose (IC50 = 38.25 ± 0.12 μM), an...

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Bibliographic Details
Published in:	European Journal of Medicinal Chemistry
Main Author:	Salar U.; Taha M.; Khan K.M.; Ismail N.H.; Imran S.; Perveen S.; Gul S.; Wadood A.
Format:	Article
Language:	English
Published:	Elsevier Masson SAS 2016
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976472588&doi=10.1016%2fj.ejmech.2016.06.037&partnerID=40&md5=f498e2221e64c88ef04a256a505b03b8

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