Empirical use of antibiotic therapy in the prevention of early onset sepsis in neonates: A pilot study

• Published in: Archives of Medical Science
• Main Author: Manan M.M.; Ibrahim N.A.; Aziz N.A.; Zulkifly H.H.; Al-Worafi Y.M.A.; Long C.M.
• Format: Review
• Language: English
• Published: Termedia Publishing House Ltd. 2016
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84973488206&doi=10.5114%2faoms.2015.51208&partnerID=40&md5=4c1cdca8f2d4ef02efc244b3e27bd83e

Introduction: To identify and assess the characteristics, risk and outcome of neonates treated with empiric antibiotics for suspected early onset sepsis (EOS). Material and methods: This is a retrospective study conducted at a Malaysian government hospital. Records of neonatal patients admitted within 72 h of life and prescribed with empirical antibiotic therapy for suspected EOS were reviewed. Results: Three hundred and twenty-three cases met the inclusion criteria and were divided into gestational age (premature < 36 weeks; term > 37 weeks) and birth weight (low birth weight (LBW) < 2.5 kg; normal body weight (NBW) > 2.5 kg) groups. Premature (n = 197) and LBW (n = 194) neonates required significantly longer hospital stay, a higher degree of ventilator support and more surfactant (p = 0.001). More than 90.0% of premature and LBW neonates were diagnosed with respiratory distress syndrome, congenital pneumonia and presumed sepsis. Term (n = 123) and NBW (n = 129) neonates had greater maternal risk factors, especially meconium-stained amniotic fluid (MSAF) and perinatal asphyxia. The incidence of demonstrated EOS was 3.1%. Crystalline penicillin plus gentamicin was the standard therapy for all groups and was started within 24 h of life, with a mean treatment duration of ∼4 days. The treatment success rate was 89.0%, and only LBW neonates showed a higher risk of overall treatment failure (OR = 3.75; 95% CI: 1.22-11.53). Seventy-four percent of term and NBW neonates discharged well, while 42.0% of premature and LBW neonates required referral. Conclusions: Crystalline penicillin plus gentamicin prescribed within 24 h of life is effective in the prevention of EOS. However, low birth weight neonates have a higher risk of treatment failure. Copyright © 2015 Termedia & Banach.