Beilschglabrines A and B: Two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra

Beilschglabrines A and B: Two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra

Two new phenanthrene alkaloids, beilschglabrines A (1) and B (2) were isolated from the stem bark of Beilschmiedia glabra, together with lupeol, taraxerol, and 24-methylenelanosta-7,9-diene-3β-15α-diol. The structures of the isolated compounds were elucidated by extensive spectroscopic data analysis...

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Published in:Phytochemistry Letters
Main Author: Salleh W.M.N.H.W.; Ahmad F.; Khong H.Y.; Zulkifli R.M.; Chen J.-J.; Nahar L.; Wansi J.D.; Sarker S.D.
Format: Article
Language:English
Published: Elsevier Ltd 2016
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964659720&doi=10.1016%2fj.phytol.2016.04.013&partnerID=40&md5=a2975f6d81f2211ef8bf44d5de8f5799
id 2-s2.0-84964659720
spelling 2-s2.0-84964659720
Salleh W.M.N.H.W.; Ahmad F.; Khong H.Y.; Zulkifli R.M.; Chen J.-J.; Nahar L.; Wansi J.D.; Sarker S.D.
Beilschglabrines A and B: Two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra
2016
Phytochemistry Letters
16

10.1016/j.phytol.2016.04.013
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964659720&doi=10.1016%2fj.phytol.2016.04.013&partnerID=40&md5=a2975f6d81f2211ef8bf44d5de8f5799
Two new phenanthrene alkaloids, beilschglabrines A (1) and B (2) were isolated from the stem bark of Beilschmiedia glabra, together with lupeol, taraxerol, and 24-methylenelanosta-7,9-diene-3β-15α-diol. The structures of the isolated compounds were elucidated by extensive spectroscopic data analysis and comparison with respective literature data. The compounds were tested for DPPH radical scavenging, acetylcholinesterase and lipoxygenase inhibitory activities. Compound 1 displayed considerable activity in the acetylcholinesterase (IC50 50.4 μM), the DPPH radical scavenging (IC50 115.9 μM) and the lipoxygenase (IC50 32.8 μM) assays. © 2016 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
Elsevier Ltd
18743900
English
Article
All Open Access; Green Open Access
author Salleh W.M.N.H.W.; Ahmad F.; Khong H.Y.; Zulkifli R.M.; Chen J.-J.; Nahar L.; Wansi J.D.; Sarker S.D.
spellingShingle Salleh W.M.N.H.W.; Ahmad F.; Khong H.Y.; Zulkifli R.M.; Chen J.-J.; Nahar L.; Wansi J.D.; Sarker S.D.
Beilschglabrines A and B: Two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra
author_facet Salleh W.M.N.H.W.; Ahmad F.; Khong H.Y.; Zulkifli R.M.; Chen J.-J.; Nahar L.; Wansi J.D.; Sarker S.D.
author_sort Salleh W.M.N.H.W.; Ahmad F.; Khong H.Y.; Zulkifli R.M.; Chen J.-J.; Nahar L.; Wansi J.D.; Sarker S.D.
title Beilschglabrines A and B: Two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra
title_short Beilschglabrines A and B: Two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra
title_full Beilschglabrines A and B: Two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra
title_fullStr Beilschglabrines A and B: Two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra
title_full_unstemmed Beilschglabrines A and B: Two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra
title_sort Beilschglabrines A and B: Two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra
publishDate 2016
container_title Phytochemistry Letters
container_volume 16
container_issue
doi_str_mv 10.1016/j.phytol.2016.04.013
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964659720&doi=10.1016%2fj.phytol.2016.04.013&partnerID=40&md5=a2975f6d81f2211ef8bf44d5de8f5799
description Two new phenanthrene alkaloids, beilschglabrines A (1) and B (2) were isolated from the stem bark of Beilschmiedia glabra, together with lupeol, taraxerol, and 24-methylenelanosta-7,9-diene-3β-15α-diol. The structures of the isolated compounds were elucidated by extensive spectroscopic data analysis and comparison with respective literature data. The compounds were tested for DPPH radical scavenging, acetylcholinesterase and lipoxygenase inhibitory activities. Compound 1 displayed considerable activity in the acetylcholinesterase (IC50 50.4 μM), the DPPH radical scavenging (IC50 115.9 μM) and the lipoxygenase (IC50 32.8 μM) assays. © 2016 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
publisher Elsevier Ltd
issn 18743900
language English
format Article
accesstype All Open Access; Green Open Access
record_format scopus
collection Scopus
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