Synthesis of 2-acylated and sulfonated 4-hydroxycoumarins: In vitro urease inhibition and molecular docking studies

QR Code

Synthesis of 2-acylated and sulfonated 4-hydroxycoumarins: In vitro urease inhibition and molecular docking studies

Sixteen 4-hydroxycoumarin derivatives were synthesized, characterized through EI-MS and 1H NMR and screened for urease inhibitory potential. Three compounds exhibited better urease inhibition than the standard inhibitor thiourea (IC50 = 21 ± 0.11 μM) while other four compounds exhibited good to mode...

Full description

Bibliographic Details
Published in:	Bioorganic Chemistry
Main Author:	Rashid U.; Rahim F.; Taha M.; Arshad M.; Ullah H.; Mahmood T.; Ali M.
Format:	Article
Language:	English
Published:	Academic Press Inc. 2016
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964603375&doi=10.1016%2fj.bioorg.2016.04.005&partnerID=40&md5=bb0716aef0a0dcb3380dd417b648b584

Similar Items

Synthesis of novel derivatives of oxindole, their urease inhibition and molecular docking studies
by: Taha M.; Ismail N.H.; Khan A.; Shah S.A.A.; Anwar A.; Halim S.A.; Fatmi M.Q.; Imran S.; Rahim F.; Khan K.M.
Published: (2015)

Synthesis, in vitro urease inhibitory potential and molecular docking study of Benzimidazole analogues
by: Zaman K.; Rahim F.; Taha M.; Ullah H.; Wadood A.; Nawaz M.; Khan F.; Wahab Z.; Shah S.A.A.; Rehman A.U.; Kawde A.-N.; Gollapalli M.
Published: (2019)

Synthesis, in vitro urease inhibitory potential and molecular docking study of benzofuran-based-thiazoldinone analogues
by: Taha M.; Rahim F.; Ullah H.; Wadood A.; Farooq R.K.; Shah S.A.A.; Nawaz M.; Zakaria Z.A.
Published: (2020)

Synthesis of 3,4,5-trihydroxybenzohydrazone and evaluation of their urease inhibition potential
by: Taha M.; Shah S.A.A.; Khan A.; Arshad F.; Ismail N.H.; Afifi M.; Imran S.; Choudhary M.I.
Published: (2019)

Novel acyl hydrazide derivatives of polyhydroquinoline as potent anti-diabetic and anti-glycating agents: Synthesis, in vitro α-amylase, α-glucosidase inhibition and anti-glycating activity with molecular docking insights
by: Ur Rahman S.; Alam A.; Parveen Z.; Zainab; Assad M.; Adnan Ali Shah S.; Rafiq H.; Ayaz M.; Latif A.; Naveed Umar M.; Ali M.; Ahmad M.
Published: (2024)

Synthesis of 4-thiazolidinone analogs as potent in vitro anti-urease agents
by: Rahim F.; Zaman K.; Ullah H.; Taha M.; Wadood A.; Javed M.T.; Rehman W.; Ashraf M.; Uddin R.; Uddin I.; Asghar H.; Khan A.A.; Khan K.M.
Published: (2015)

Exploring Acyl Thiotriazinoindole Based Pharmacophores: Design, Synthesis, and SAR Studies with Molecular Docking and Biological Activity Profiling against Urease, α-amylase, α-glucosidase, Antimicrobial, and Antioxidant Targets
by: Haider, et al.
Published: (2024)

Exploring Acyl Thiotriazinoindole Based Pharmacophores: Design, Synthesis, and SAR Studies with Molecular Docking and Biological Activity Profiling against Urease, α-amylase, α-glucosidase, Antimicrobial, and Antioxidant Targets
by: Haider M.B.; Saeed A.; Ahmed A.; Azeem M.; Ismail H.; Mehmood S.; Taslimi P.; Shah S.A.A.; Irfan M.; El-Seedi H.R.
Published: (2024)

Synthesis, In Vitro Enzymatic Inhibition, and Molecular Modeling of Novel Piperazine-Based Bis-Schiff Base Derivatives as Promising Anti-urease Agents
by: Masood N.; Hussain R.; Khan S.; Rahim F.; Mumtaz S.; Taha M.; Ur Rahman Abid O.; Iqbal T.; Adnan Ali Shah S.; Omar Al Wesabi E.; Magam S.M.
Published: (2024)

Synthesis, In Vitro Enzymatic Inhibition, and Molecular Modeling of Novel Piperazine-Based Bis-Schiff Base Derivatives as Promising Anti-urease Agents
by: Masood, et al.
Published: (2024)

Synthesis, thymidine phosphorylase, angiogenic inhibition and molecular docking study of isoquinoline derivatives
by: Zaman K.; Rahim F.; Taha M.; Wadood A.; Adnan Ali Shah S.; Gollapalli M.; Ullah F.; Ahmed A.
Published: (2019)

Design, synthesis, in vitro evaluation, molecular docking and ADME properties studies of hybrid bis-coumarin with thiadiazole as a new inhibitor of Urease
by: Alomari M.; Taha M.; Imran S.; Jamil W.; Selvaraj M.; Uddin N.; Rahim F.
Published: (2019)

Synthesis of potent urease inhibitors based on disulfide scaffold and their molecular docking studies
by: Taha M.; Ismail N.H.; Imran S.; Wadood A.; Rahim F.; Riaz M.
Published: (2015)

Synthesis, β-Glucuronidase Inhibition, and Molecular Docking Studies of 1,2,4-Triazole Hydrazones
by: Jamil W.; Kumari D.; Taha M.; Khan M.N.; Baharudin M.S.; Ali M.; Kanwal M.; Lashari M.S.; Khan K.M.
Published: (2018)

Synthesis, β-glucuronidase inhibition and molecular docking studies of hybrid bisindole-thiosemicarbazides analogs
by: Taha M.; Ismail N.H.; Imran S.; Rahim F.; Wadood A.; Khan H.; Ullah H.; Salar U.; Khan K.M.
Published: (2016)

Synthesis of new arylhydrazide bearing Schiff bases/thiazolidinone: α-Amylase, urease activities and their molecular docking studies
by: Rahim F.; Taha M.; Ullah H.; Wadood A.; Selvaraj M.; Rab A.; Sajid M.; Shah S.A.A.; Uddin N.; Gollapalli M.
Published: (2019)

Benzoxazole based thiazole hybrid analogs: Synthesis, in vitro cholinesterase inhibition, and molecular docking studies
by: Hussain R.; Rahim F.; Rehman W.; Adnan Ali Shah S.; Khan S.; Khan I.; Rasheed L.; Imran S.; Wadood A.; Abdellatif M.H.
Published: (2023)

Synthesis, In Vitro α-Amylase Activity, and Molecular Docking Study of New Benzimidazole Derivatives
by: Ullah H.; Ullah H.; Taha M.; Khan F.; Rahim F.; Uddin I.; Sarfraz M.; Shah S.A.A.; Aziz A.; Mubeen S.
Published: (2021)

Development of bis-thiobarbiturates as successful urease inhibitors and their molecular modeling studies
by: Rahim F.; Ali M.; Ullah S.; Rashid U.; Ullah H.; Taha M.; Javed M.T.; Rehman W.; Khan A.A.; Abid O.U.R.; Bilal M.
Published: (2016)

Synthesis, molecular docking study and in vitro thymidine phosphorylase inhibitory potential of oxadiazole derivatives
by: Ullah H.; Rahim F.; Taha M.; Uddin I.; Wadood A.; Shah S.A.A.; Farooq R.K.; Nawaz M.; Wahab Z.; Khan K.M.
Published: (2018)

Synthesis of novel N-(1,3-thiazol-2-yl)benzamide clubbed oxadiazole scaffolds: Urease inhibition, Lipinski rule and molecular docking analyses
by: Athar Abbasi M.; Raza H.; Aziz-ur-Rehman; Zahra Siddiqui S.; Adnan Ali Shah S.; Hassan M.; Seo S.-Y.
Published: (2019)

Synthesis, α-glucosidase inhibition and molecular docking study of coumarin based derivatives
by: Taha M.; Shah S.A.A.; Afifi M.; Imran S.; Sultan S.; Rahim F.; Khan K.M.
Published: (2018)

Bisindolylmethane thiosemicarbazides as potential inhibitors of urease: Synthesis and molecular modeling studies
by: Taha M.; Ullah H.; Al Muqarrabun L.M.R.; Khan M.N.; Rahim F.; Ahmat N.; Javid M.T.; Ali M.; Khan K.M.
Published: (2018)

Synthesis, α-amylase inhibition and molecular docking study of bisindolylmethane sulfonamide derivatives
by: Taha M.; Noreen T.; Imran S.; Nawaz F.; Chigurupati S.; Selvaraj M.; Rahim F.; Hadiani Ismail N.; Kumar A.; Mosaddik A.; Alghamdi A.M.; Abdulrahman nasser alqahtani Y.; Abdulrahman nasser alqahtani A.
Published: (2019)

Synthesis, in vitro α-glucosidase activity and in silico molecular docking study of isatin analogues
by: Ullah H.; Rahim F.; Ullah E.; Hayat S.; Zada H.; Khan F.; Wadood A.; Nawaz F.; Rehman Z.U.; Shah S.A.A.
Published: (2023)

Synthesis, in vitro evaluation and molecular docking studies of thiazole derivatives as new inhibitors of α-glucosidase
by: Rahim F.; Ullah H.; Javid M.T.; Wadood A.; Taha M.; Ashraf M.; Shaukat A.; Junaid M.; Hussain S.; Rehman W.; Mehmood R.; Sajid M.; Khan M.N.; Khan K.M.
Published: (2015)

Synthesis, molecular docking and α-glucosidase inhibition of 5-aryl-2-(6′-nitrobenzofuran-2′-yl)-1,3,4-oxadiazoles
by: Taha M.; Ismail N.H.; Imran S.; Wadood A.; Rahim F.; Saad S.M.; Khan K.M.; Nasir A.
Published: (2016)

Synthesis of novel flavone hydrazones: In-vitro evaluation of α-glucosidase inhibition, QSAR analysis and docking studies
by: Imran S.; Taha M.; Ismail N.H.; Kashif S.M.; Rahim F.; Jamil W.; Hariono M.; Yusuf M.; Wahab H.
Published: (2015)

Isatin based Schiff bases as inhibitors of α-glucosidase: Synthesis, characterization, in vitro evaluation and molecular docking studies
by: Rahim F.; Malik F.; Ullah H.; Wadood A.; Khan F.; Javid M.T.; Taha M.; Rehman W.; Ur Rehman A.; Khan K.M.
Published: (2015)

Synthesis, β-glucuronidase inhibition and molecular docking studies of cyano-substituted bisindole hydrazone hybrids
by: Abid O.; Imran S.; Taha M.; Ismail N.H.; Jamil W.; Kashif S.M.; Khan K.M.; Yusoff J.
Published: (2021)

Synthesis crystal structure of 2-methoxybenzoylhydrazones and evaluation of their α-glucosidase and urease inhibition potential
by: Taha M.; Ismail N.H.; Baharudin M.S.; Lalani S.; Mehboob S.; Khan K.M.; Yousuf S.; Siddiqui S.; Rahim F.; Choudhary M.I.
Published: (2015)

Synthesis, in vitro alpha-glucosidase inhibitory potential of benzimidazole bearing bis-Schiff bases and their molecular docking study
by: Rahim F.; Zaman K.; Taha M.; Ullah H.; Ghufran M.; Wadood A.; Rehman W.; Uddin N.; Shah S.A.A.; Sajid M.; Nawaz F.; Khan K.M.
Published: (2020)

New thiazole-based thiazolidinone derivatives: Synthesis, in vitro α-amylase, α-glucosidase activities and silico molecular docking study
by: Khan S.; Ullah H.; Rahim F.; Taha M.; Hussain R.; Khan M.S.; Ali H.; Khan M.U.; Shah S.A.A.; Khan K.M.
Published: (2022)

Synthesis of Flurbiprofen Based Amide Derivatives as Potential Leads for Diabetic Management: In Vitro α-glucosidase Inhibition, Molecular Docking and DFT Simulation Approach
by: Alam A.; Zainab; Elhenawy A.A.; Ur Rehman N.; Shahidul Islam M.; Dahlous K.A.; Talab F.; Shah S.A.A.; Ali M.; Ahmad M.
Published: (2024)

Synthesis, in vitro α-glucosidase inhibitory potential and molecular docking study of thiadiazole analogs
by: Javid M.T.; Rahim F.; Taha M.; Rehman H.U.; Nawaz M.; wadood A.; Imran S.; Uddin I.; Mosaddik A.; Khan K.M.
Published: (2018)

Syntheses, in vitro evaluation and molecular docking studies of 5-bromo-2-aryl benzimidazoles as α-glucosidase inhibitors
by: Arshad T.; Khan K.M.; Rasool N.; Salar U.; Hussain S.; Tahir T.; Ashraf M.; Wadood A.; Riaz M.; Perveen S.; Taha M.; Ismail N.H.
Published: (2016)

Synthesis, in vitro α-glucosidase inhibitory activity and molecular docking studies of new thiazole derivatives
by: Khan K.M.; Qurban S.; Salar U.; Taha M.; Hussain S.; Perveen S.; Hameed A.; Ismail N.H.; Riaz M.; Wadood A.
Published: (2016)

Exploring Novel Pyridine Carboxamide Derivatives as Urease Inhibitors: Synthesis, Molecular Docking, Kinetic Studies and ADME Profile
by: Naseer A.; Osra F.A.; Awan A.N.; Imran A.; Hameed A.; Ali Shah S.A.; Iqbal J.; Zakaria Z.A.
Published: (2022)

Synthesis, in vitro evaluation and molecular docking studies of biscoumarin thiourea as a new inhibitor of α-glucosidases
by: Zawawi N.K.N.A.; Taha M.; Ahmat N.; Ismail N.H.; Wadood A.; Rahim F.; Rehman A.U.
Published: (2015)

Synthesis, in vitro evaluation and molecular docking studies of hybrid 4-quinolinyl bearing 1,3,4-thiadiazole-2-amine as a new inhibitor of α-amylase and α-glucosidase
by: Taha M.; Khan A.A.; Rahim F.; Hayat S.; Imran S.; Iqbal N.; Uddin N.; Khan K.M.; Anouar E.H.; Farooq R.K.; Nawaz M.; Shah S.A.A.
Published: (2023)