Antidiabetic and antihypercholesterolemic activities of Citrus sinensis peel: In vivo study
Background: Fruit peels are still regarded as useless materials and wastes; however, the chemical content in these fruit peels have pharmacological activities. Aims and Objective: To determine the in vivo antidiabetic and antihypercholesterolemic activities of sweet orange fruit peels extract. Mater...
Published in: | National Journal of Physiology, Pharmacy and Pharmacology |
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Mrs Deepika Charan
2015
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2-s2.0-84961357056 Muhtadi; Haryoto; Azizah T.; Suhendi A.; Yen K.H. Antidiabetic and antihypercholesterolemic activities of Citrus sinensis peel: In vivo study 2015 National Journal of Physiology, Pharmacy and Pharmacology 5 5 10.5455/njppp.2015.5.2807201561 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961357056&doi=10.5455%2fnjppp.2015.5.2807201561&partnerID=40&md5=3c1e8e1af8050f88160084fe1dc0017b Background: Fruit peels are still regarded as useless materials and wastes; however, the chemical content in these fruit peels have pharmacological activities. Aims and Objective: To determine the in vivo antidiabetic and antihypercholesterolemic activities of sweet orange fruit peels extract. Materials and Methods: The study was conducted based on pre- and posttesting groups design with control. Twenty-five rats were divided into five groups—group I, negative control (0.5% CMC-Na); group II, positive control (glibenclamide and simvastatin); groups III, IV, and V were given sweet orange peel extract doses of 125, 250, and 500 mg/kg body weight (BW), respectively. For the antidiabetic study, the rats were induced by alloxan monohydrate (150 mg/kg BW intraperitoneally), and the blood glucose levels 4 days later were ± 200 mg/dL, which is a diabetic condition. Meanwhile, a hypercholesterolemic study was carried out by providing by a high-fat feed and feed high-fat diet to achieve blood cholesterol levels at values > 130 mg/dL. Result: The study showed that the sweet orange peel extract of these doses could reduce blood glucose levels with decreasing values of 39.24% ± 4.96%, 46.18% ± 6.60%, and 61.36% ± 5.57% in groups III–V, respectively. The most interesting feature was the activity of extracts in lowering blood cholesterol levels, which was almost similar, with the value around 55%, and this activity was higher than cholesteramine (800 mg/kg BW), for which the value was 34.20% ± 10.48%. Conclusion: The extract of Citrus sinensis peels with dose of 500 mg/kg BW showed the highest antidiabetic and antihypercholesterolemic activities in rats models. © 2015 Muhtadi. Mrs Deepika Charan 23204672 English Article |
author |
Muhtadi; Haryoto; Azizah T.; Suhendi A.; Yen K.H. |
spellingShingle |
Muhtadi; Haryoto; Azizah T.; Suhendi A.; Yen K.H. Antidiabetic and antihypercholesterolemic activities of Citrus sinensis peel: In vivo study |
author_facet |
Muhtadi; Haryoto; Azizah T.; Suhendi A.; Yen K.H. |
author_sort |
Muhtadi; Haryoto; Azizah T.; Suhendi A.; Yen K.H. |
title |
Antidiabetic and antihypercholesterolemic activities of Citrus sinensis peel: In vivo study |
title_short |
Antidiabetic and antihypercholesterolemic activities of Citrus sinensis peel: In vivo study |
title_full |
Antidiabetic and antihypercholesterolemic activities of Citrus sinensis peel: In vivo study |
title_fullStr |
Antidiabetic and antihypercholesterolemic activities of Citrus sinensis peel: In vivo study |
title_full_unstemmed |
Antidiabetic and antihypercholesterolemic activities of Citrus sinensis peel: In vivo study |
title_sort |
Antidiabetic and antihypercholesterolemic activities of Citrus sinensis peel: In vivo study |
publishDate |
2015 |
container_title |
National Journal of Physiology, Pharmacy and Pharmacology |
container_volume |
5 |
container_issue |
5 |
doi_str_mv |
10.5455/njppp.2015.5.2807201561 |
url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961357056&doi=10.5455%2fnjppp.2015.5.2807201561&partnerID=40&md5=3c1e8e1af8050f88160084fe1dc0017b |
description |
Background: Fruit peels are still regarded as useless materials and wastes; however, the chemical content in these fruit peels have pharmacological activities. Aims and Objective: To determine the in vivo antidiabetic and antihypercholesterolemic activities of sweet orange fruit peels extract. Materials and Methods: The study was conducted based on pre- and posttesting groups design with control. Twenty-five rats were divided into five groups—group I, negative control (0.5% CMC-Na); group II, positive control (glibenclamide and simvastatin); groups III, IV, and V were given sweet orange peel extract doses of 125, 250, and 500 mg/kg body weight (BW), respectively. For the antidiabetic study, the rats were induced by alloxan monohydrate (150 mg/kg BW intraperitoneally), and the blood glucose levels 4 days later were ± 200 mg/dL, which is a diabetic condition. Meanwhile, a hypercholesterolemic study was carried out by providing by a high-fat feed and feed high-fat diet to achieve blood cholesterol levels at values > 130 mg/dL. Result: The study showed that the sweet orange peel extract of these doses could reduce blood glucose levels with decreasing values of 39.24% ± 4.96%, 46.18% ± 6.60%, and 61.36% ± 5.57% in groups III–V, respectively. The most interesting feature was the activity of extracts in lowering blood cholesterol levels, which was almost similar, with the value around 55%, and this activity was higher than cholesteramine (800 mg/kg BW), for which the value was 34.20% ± 10.48%. Conclusion: The extract of Citrus sinensis peels with dose of 500 mg/kg BW showed the highest antidiabetic and antihypercholesterolemic activities in rats models. © 2015 Muhtadi. |
publisher |
Mrs Deepika Charan |
issn |
23204672 |
language |
English |
format |
Article |
accesstype |
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record_format |
scopus |
collection |
Scopus |
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1818940563960889344 |