Thiadiazole derivatives as New Class of β-glucuronidase inhibitors

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Thiadiazole derivatives as New Class of β-glucuronidase inhibitors

Thiadiazole derivatives 1-24 were synthesized via a single step reaction and screened for in vitro β-glucuronidase inhibitory activity. All the synthetic compounds displayed good inhibitory activity in the range of IC50 = 2.16 ± 0.01-58.06 ± 1.60 μM as compare to standard d-saccharic acid 1,4-lacton...

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Bibliographic Details
Published in:	Bioorganic and Medicinal Chemistry
Main Author:	Salar U.; Taha M.; Ismail N.H.; Khan K.M.; Imran S.; Perveen S.; Wadood A.; Riaz M.
Format:	Article
Language:	English
Published:	Elsevier Ltd 2016
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961126449&doi=10.1016%2fj.bmc.2016.03.020&partnerID=40&md5=77d703360524d538921852b32b015a5b

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