Solubility enhancement of simvastatin by arginine: Thermodynamics, solute–solvent interactions, and spectral analysis
We examined the solubility of simvastatin in water in 0.01 mol⋅dm−3, 0.02 mol⋅dm−3, 0.04 mol⋅dm−3, 0.09 mol⋅dm−3, 0.18 mol⋅dm−3, 0.36 mol⋅dm−3, and 0.73 mol⋅dm−3 arginine (ARG) solutions. The investigated drug is termed the solute, whereas ARG the cosolute. Phase solubility studies illustrated a hig...
| Published in: | Drug Design, Development and Therapy |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press Ltd.
2016
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84959575598&doi=10.2147%2fDDDT.S94701&partnerID=40&md5=5dcf96f72ca3366a5ea93c26d0dd6a35 |