Solubility enhancement of simvastatin by arginine: Thermodynamics, solute–solvent interactions, and spectral analysis

• Published in: Drug Design, Development and Therapy
• Main Author: Meor Mohd Affandi M.M.R.; Tripathy M.; Ali Shah S.A.; Majeed A.B.A.
• Format: Article
• Language: English
• Published: Dove Medical Press Ltd. 2016
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84959575598&doi=10.2147%2fDDDT.S94701&partnerID=40&md5=5dcf96f72ca3366a5ea93c26d0dd6a35

We examined the solubility of simvastatin in water in 0.01 mol⋅dm−3, 0.02 mol⋅dm−3, 0.04 mol⋅dm−3, 0.09 mol⋅dm−3, 0.18 mol⋅dm−3, 0.36 mol⋅dm−3, and 0.73 mol⋅dm−3 arginine (ARG) solutions. The investigated drug is termed the solute, whereas ARG the cosolute. Phase solubility studies illustrated a higher extent of solubility enhancement for simvastatin. The aforemen­tioned system was subjected to conductometric and volumetric measurements at temperatures (T) of 298.15 K, 303.15 K, 308.15 K, and 313.15 K to illustrate the thermodynamics involved and related solute–solvent interactions. The conductance values were used to evaluate the limiting molar conductance and association constants. Thermodynamic parameters (ΔG0, ΔH0, ΔS0, and Es) for the association process of the solute in the aqueous solutions of ARG were calculated. Limiting partial molar volumes and expansibilities were evaluated from the density values. These values are discussed in terms of the solute–solvent and solute–cosolute interac­tions. Further, these systems were analyzed using ultraviolet–visible analysis, Fourier-transform infrared spectroscopy, and13C,1H, and two-dimensional nuclear overhauser effect spectroscopy nuclear magnetic resonance to complement thermophysical explanation. © 2016 Meor Mohd Affandi et al.