Synthesis of 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives and evaluation of their antiglycation potential

Synthesis of 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives and evaluation of their antiglycation potential

In the search of potent antidiabetic drug, we synthesized 1-25 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives. First, we synthesized 2-methoxybenzohydrazide from methyl 2-methoxybenzoate which was treated with different arylaldehydes to afford 1-25 compounds. The synthesized compounds wer...

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Published in:Medicinal Chemistry Research
Main Author: Taha M.; Ismail N.H.; Jamil W.; Imran S.; Rahim F.; Kashif S.M.; Zulkefeli M.
Format: Article
Language:English
Published: Birkhauser Boston 2016
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84954227341&doi=10.1007%2fs00044-015-1476-8&partnerID=40&md5=3b4ae811d3f2efc065a479b4cfd60b6f
id 2-s2.0-84954227341
spelling 2-s2.0-84954227341
Taha M.; Ismail N.H.; Jamil W.; Imran S.; Rahim F.; Kashif S.M.; Zulkefeli M.
Synthesis of 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives and evaluation of their antiglycation potential
2016
Medicinal Chemistry Research
25
2
10.1007/s00044-015-1476-8
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84954227341&doi=10.1007%2fs00044-015-1476-8&partnerID=40&md5=3b4ae811d3f2efc065a479b4cfd60b6f
In the search of potent antidiabetic drug, we synthesized 1-25 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives. First, we synthesized 2-methoxybenzohydrazide from methyl 2-methoxybenzoate which was treated with different arylaldehydes to afford 1-25 compounds. The synthesized compounds were evaluated for antiglycation activity. We found that 1-6 and 8 showed potent activity ranging from 160.2 to 290.17 μM better than standard drug rutin (IC50 = 295.09 ± 1.04 μM). All the synthesized compounds were characterized by different spectroscopy methods. These compounds can further be studied to develop lead antidiabetic compounds. © 2015 Springer Science+Business Media New York.
Birkhauser Boston
10542523
English
Article
author Taha M.; Ismail N.H.; Jamil W.; Imran S.; Rahim F.; Kashif S.M.; Zulkefeli M.
spellingShingle Taha M.; Ismail N.H.; Jamil W.; Imran S.; Rahim F.; Kashif S.M.; Zulkefeli M.
Synthesis of 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives and evaluation of their antiglycation potential
author_facet Taha M.; Ismail N.H.; Jamil W.; Imran S.; Rahim F.; Kashif S.M.; Zulkefeli M.
author_sort Taha M.; Ismail N.H.; Jamil W.; Imran S.; Rahim F.; Kashif S.M.; Zulkefeli M.
title Synthesis of 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives and evaluation of their antiglycation potential
title_short Synthesis of 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives and evaluation of their antiglycation potential
title_full Synthesis of 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives and evaluation of their antiglycation potential
title_fullStr Synthesis of 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives and evaluation of their antiglycation potential
title_full_unstemmed Synthesis of 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives and evaluation of their antiglycation potential
title_sort Synthesis of 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives and evaluation of their antiglycation potential
publishDate 2016
container_title Medicinal Chemistry Research
container_volume 25
container_issue 2
doi_str_mv 10.1007/s00044-015-1476-8
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-84954227341&doi=10.1007%2fs00044-015-1476-8&partnerID=40&md5=3b4ae811d3f2efc065a479b4cfd60b6f
description In the search of potent antidiabetic drug, we synthesized 1-25 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives. First, we synthesized 2-methoxybenzohydrazide from methyl 2-methoxybenzoate which was treated with different arylaldehydes to afford 1-25 compounds. The synthesized compounds were evaluated for antiglycation activity. We found that 1-6 and 8 showed potent activity ranging from 160.2 to 290.17 μM better than standard drug rutin (IC50 = 295.09 ± 1.04 μM). All the synthesized compounds were characterized by different spectroscopy methods. These compounds can further be studied to develop lead antidiabetic compounds. © 2015 Springer Science+Business Media New York.
publisher Birkhauser Boston
issn 10542523
language English
format Article
accesstype
record_format scopus
collection Scopus
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