Synthesis of 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives and evaluation of their antiglycation potential
In the search of potent antidiabetic drug, we synthesized 1-25 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives. First, we synthesized 2-methoxybenzohydrazide from methyl 2-methoxybenzoate which was treated with different arylaldehydes to afford 1-25 compounds. The synthesized compounds wer...
| Published in: | Medicinal Chemistry Research |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Birkhauser Boston
2016
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84954227341&doi=10.1007%2fs00044-015-1476-8&partnerID=40&md5=3b4ae811d3f2efc065a479b4cfd60b6f |
| Summary: | In the search of potent antidiabetic drug, we synthesized 1-25 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives. First, we synthesized 2-methoxybenzohydrazide from methyl 2-methoxybenzoate which was treated with different arylaldehydes to afford 1-25 compounds. The synthesized compounds were evaluated for antiglycation activity. We found that 1-6 and 8 showed potent activity ranging from 160.2 to 290.17 μM better than standard drug rutin (IC50 = 295.09 ± 1.04 μM). All the synthesized compounds were characterized by different spectroscopy methods. These compounds can further be studied to develop lead antidiabetic compounds. © 2015 Springer Science+Business Media New York. |
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| ISSN: | 10542523 |
| DOI: | 10.1007/s00044-015-1476-8 |