Antioxidant and α-glucosidase inhibitory constituents from Hornstedtia species of Malaysia

• Published in: Natural Product Communications
• Main Author: Hashim S.E.; Sirat H.M.; Yen K.H.; Ismail I.S.; Matsuki S.N.
• Format: Article
• Language: English
• Published: Natural Product Incorporation 2015
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84949997360&doi=10.1177%2f1934578x1501000919&partnerID=40&md5=87d8a1814164b169cffa71519bd1d682

Seven compounds were isolated from the n-hexane and chloroform extracts of the flowers and leaves of four Hornstedtia species and their structures were identified using spectroscopic techniques as 3,7,4′-trimethylkaempferol (1), 3,7-dimethylkaempferol (2), 7,4′-dimethylkaempferol (3), 3,5-dimethylkaempferol (4), 3-methylkaempferol (5), stigmast-4-en-3-one (6), and 6-hydroxy-stigmast-4-en-3-one (7). Compounds 1 to 7 were isolated from these species for the first time. They were assayed for free radical scavenging and α-glucosidase inhibition activities. The DPPH assay showed that 3-methylkaempferol (5) was the most potent antioxidant agent with an IC50 value 78.6 μM, followed by 7,4′-dimethylkaempferol (3) (IC50 = 86.1 μM). For α-glucosidase inhibition activity, 3-methylkaempferol (5) exhibited significant inhibitory activity with an IC50 value 21.0 μM. The present study revealed that Hornstedtia species have potential activities as antioxidant and α-glucosidase inhibitors.