Characterization of crosslinked zerumbone loaded gelatin – Zeolite Y hybrid composites with glutaraldehyde for controlled release of natural anticancer drug; [Pencirian sambung silang zerumbon dimuatkan dalam gelatin-zeolit Y komposit hibrid dengan glutaraldehid untuk pembebasan terkawal ubat anti-kanser semulajadi]

• Published in: Malaysian Journal of Analytical Sciences
• Main Author: Salleh N.; Jais U.S.; Sarijo S.H.
• Format: Article
• Language: English
• Published: Malaysian Society of Analytical Sciences 2015
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84949741504&partnerID=40&md5=21288a75f06486353e8c42784f367c71
• ISSN: 13942506

Zeolite Y-gelatin hybrid spherical pellets were prepared by blending zerumbone loaded zeolite Y with gelatin solution and crosslinking achieved by glutaraldehyde. The pellets were characterized by using ATR-FTIR spectroscopy, Raman spectroscopy, thermogravimetric analysis (TGA) and swelling analysis. The zerumbone entrapment in zeolite Y was calculated via UV-VIS and results showed that zerumbone could be encapsulated to the maximum loading of porous zeolite Y. ATR-FTIR analysis showed the inert property of zeolite Y that only act as porous host carrier and crosslinking was achieved at 1650 cm-1. Result from Raman spectra supported and proven that crosslinking occur at 1650 cm-1. The swelling of crosslinked samples showed slower water penetration indicating that crosslinking had strengthened the spherical pellets. TGA results supported that after crosslinking took place, the thermal decomposition temperature for the composite increased indicating the increase of composite strength. This study showed promising results towards the composite development in controlled drug release area. © 2015, Malaysian Society of Analytical Sciences. All rights reserved.