Synthesis of novel benzohydrazone-oxadiazole hybrids as β-glucuronidase inhibitors and molecular modeling studies

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Synthesis of novel benzohydrazone-oxadiazole hybrids as β-glucuronidase inhibitors and molecular modeling studies

A series of compounds consisting of 25 novel oxadiazole-benzohydrazone hybrids (6-30) were synthesized through a five-step reaction sequence and evaluated for their β-glucuronidase inhibitory potential. The IC50 values of compounds 6-30 were found to be in the range of 7.14-44.16 μM. Compounds 6, 7,...

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Bibliographic Details
Published in:	Bioorganic and Medicinal Chemistry
Main Author:	Taha M.; Ismail N.H.; Imran S.; Selvaraj M.; Rahim A.; Ali M.; Siddiqui S.; Rahim F.; Khan K.M.
Format:	Article
Language:	English
Published:	Elsevier Ltd 2015
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84947598255&doi=10.1016%2fj.bmc.2015.10.037&partnerID=40&md5=f5ac770fd89b6961af1fb80996b337cc

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