Novel quinoline derivatives as potent in vitro α-glucosidase inhibitors: In silico studies and SAR predictions

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Novel quinoline derivatives as potent in vitro α-glucosidase inhibitors: In silico studies and SAR predictions

A new series of quinoline derivatives 6-30 was identified as potent α-glucosidase inhibitors. These analogs exhibited inhibitory potentials (IC50 values) in the ranges between 2.60 and 102.12 μM. Among the series, compounds 24 (2.60 ± 0.01 μM), 27 (2.60 ± 0.01 μM) and 20 (2.86 ± 0.01 μM) were found...

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Bibliographic Details
Published in:	MedChemComm
Main Author:	Taha M.; Ismail N.H.; Imran S.; Wadood A.; Rahim F.; Ali M.; Rehman A.U.
Format:	Article
Language:	English
Published:	Royal Society of Chemistry 2015
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84943771420&doi=10.1039%2fc5md00280j&partnerID=40&md5=ee5961423c8fb138efab5ae30ca1e63e

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