Phylogenetic relationship of non-typeable Haemophilus influenzae isolated in Malaysia

The epidemiology of non-typeable Haemophilus influenzae (NTHi) remains poorly understood. We therefore sought to determine the genetic relationship of 25 NTHi isolated from various states in Malaysia using multilocus sequence typing (MLST). The majority of isolates were obtained from sputum. There w...

Full description

Bibliographic Details
Published in:Infection, Genetics and Evolution
Main Author: Mohd-Zain Z.; Kamsani N.H.; Ahmad N.; Clarke S.C.
Format: Article
Language:English
Published: Elsevier B.V. 2015
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84943620835&doi=10.1016%2fj.meegid.2015.09.017&partnerID=40&md5=c11f450eaad95b96660a4420529d74db
Description
Summary:The epidemiology of non-typeable Haemophilus influenzae (NTHi) remains poorly understood. We therefore sought to determine the genetic relationship of 25 NTHi isolated from various states in Malaysia using multilocus sequence typing (MLST). The majority of isolates were obtained from sputum. There were 24 novel sequence types (STs). Eight isolates were single-locus variants, the remainder being singletons. Clustering was not based on clinical site of isolation or geographical origin. Despite the limited number of isolates examined in this study, we demonstrate that NTHi isolates in Malaysia are diverse and warrant further investigation. © 2015 Elsevier B.V.
ISSN:15671348
DOI:10.1016/j.meegid.2015.09.017