Evaluation of 2-indolcarbohydrazones as potent α-glucosidase inhibitors, in silico studies and DFT based stereochemical predictions
2-Indolcarbohydrazones 1-28 were synthesized and evaluated for their α-glucosidase inhibitory potential. A varying degree of inhibitory potential with IC50 values in the range of 2.3 ± 0.11-226.4 ± 6.8 μM was observed while comparing these outcomes with the standard acarbose (IC50 = 906.0±6.3μM). Th...
Published in: | Bioorganic Chemistry |
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Main Author: | |
Format: | Article |
Language: | English |
Published: |
Academic Press Inc.
2015
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Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84942794211&doi=10.1016%2fj.bioorg.2015.09.001&partnerID=40&md5=ab9d824d62006e2a5510d5dd701506c3 |