Synthesis, molecular docking, acetylcholinesterase and butyrylcholinesterase inhibitory potential of thiazole analogs as new inhibitors for Alzheimer disease

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Synthesis, molecular docking, acetylcholinesterase and butyrylcholinesterase inhibitory potential of thiazole analogs as new inhibitors for Alzheimer disease

A series of thirty (30) thiazole analogs were prepared, characterized by 1H NMR, 13C NMR and EI-MS and evaluated for Acetylcholinesterase and butyrylcholinesterase inhibitory potential. All analogs exhibited varied butyrylcholinesterase inhibitory activity with IC50 value ranging between 1.59 ± 0.01...

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Bibliographic Details
Published in:	Bioorganic Chemistry
Main Author:	Rahim F.; Javed M.T.; Ullah H.; Wadood A.; Taha M.; Ashraf M.; Qurat-Ul-Ain; Khan M.A.; Khan F.; Mirza S.; Khan K.M.
Format:	Article
Language:	English
Published:	Academic Press Inc. 2015
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84940020718&doi=10.1016%2fj.bioorg.2015.08.002&partnerID=40&md5=7105aa5a0971138a2feb2a54448372d9

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