Synthesis of benzophenone hydrazone analogs and their DPPH radical scavenging and urease inhibitory activities

Synthesis of benzophenone hydrazone analogs and their DPPH radical scavenging and urease inhibitory activities

Benzophenone hydrazone analogs 1-25 were synthesized and evaluated for antioxidant (DPPH radical scavenging), and urease inhibitory activities. Out of twenty-five analogs, compounds 8, 23, and 1 showed potent free radical scavenging activities with IC50 values 19.45 ± 1.25, 21.72 ± 1.49, and 26.0 ±...

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Published in:Journal of the Chemical Society of Pakistan
Main Author: Khan K.M.; Rahim F.; Khan A.; Ali S.; Taha M.; Saad S.M.; Khan M.; Najeebullah; Shaikh A.; Perveen S.; Choudhary M.I.
Format: Article
Language:English
Published: Chemical Society of Pakistan 2015
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84937831128&partnerID=40&md5=310b2153b6efc997fe232f52ca8bd606
id 2-s2.0-84937831128
spelling 2-s2.0-84937831128
Khan K.M.; Rahim F.; Khan A.; Ali S.; Taha M.; Saad S.M.; Khan M.; Najeebullah; Shaikh A.; Perveen S.; Choudhary M.I.
Synthesis of benzophenone hydrazone analogs and their DPPH radical scavenging and urease inhibitory activities
2015
Journal of the Chemical Society of Pakistan
37
3

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84937831128&partnerID=40&md5=310b2153b6efc997fe232f52ca8bd606
Benzophenone hydrazone analogs 1-25 were synthesized and evaluated for antioxidant (DPPH radical scavenging), and urease inhibitory activities. Out of twenty-five analogs, compounds 8, 23, and 1 showed potent free radical scavenging activities with IC50 values 19.45 ± 1.25, 21.72 ± 1.49, and 26.0 ± 0.52 μM, respectively, while compound 8 (IC50 = 36.36 ± 0.94 μM), and 15 (IC50 = 55.5 ± 0.69 μM), showed good to moderate urease inhibitory potential. © 2015, Chemical Society of Pakistan. All rights reserved.
Chemical Society of Pakistan
2535106
English
Article
author Khan K.M.; Rahim F.; Khan A.; Ali S.; Taha M.; Saad S.M.; Khan M.; Najeebullah; Shaikh A.; Perveen S.; Choudhary M.I.
spellingShingle Khan K.M.; Rahim F.; Khan A.; Ali S.; Taha M.; Saad S.M.; Khan M.; Najeebullah; Shaikh A.; Perveen S.; Choudhary M.I.
Synthesis of benzophenone hydrazone analogs and their DPPH radical scavenging and urease inhibitory activities
author_facet Khan K.M.; Rahim F.; Khan A.; Ali S.; Taha M.; Saad S.M.; Khan M.; Najeebullah; Shaikh A.; Perveen S.; Choudhary M.I.
author_sort Khan K.M.; Rahim F.; Khan A.; Ali S.; Taha M.; Saad S.M.; Khan M.; Najeebullah; Shaikh A.; Perveen S.; Choudhary M.I.
title Synthesis of benzophenone hydrazone analogs and their DPPH radical scavenging and urease inhibitory activities
title_short Synthesis of benzophenone hydrazone analogs and their DPPH radical scavenging and urease inhibitory activities
title_full Synthesis of benzophenone hydrazone analogs and their DPPH radical scavenging and urease inhibitory activities
title_fullStr Synthesis of benzophenone hydrazone analogs and their DPPH radical scavenging and urease inhibitory activities
title_full_unstemmed Synthesis of benzophenone hydrazone analogs and their DPPH radical scavenging and urease inhibitory activities
title_sort Synthesis of benzophenone hydrazone analogs and their DPPH radical scavenging and urease inhibitory activities
publishDate 2015
container_title Journal of the Chemical Society of Pakistan
container_volume 37
container_issue 3
doi_str_mv
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-84937831128&partnerID=40&md5=310b2153b6efc997fe232f52ca8bd606
description Benzophenone hydrazone analogs 1-25 were synthesized and evaluated for antioxidant (DPPH radical scavenging), and urease inhibitory activities. Out of twenty-five analogs, compounds 8, 23, and 1 showed potent free radical scavenging activities with IC50 values 19.45 ± 1.25, 21.72 ± 1.49, and 26.0 ± 0.52 μM, respectively, while compound 8 (IC50 = 36.36 ± 0.94 μM), and 15 (IC50 = 55.5 ± 0.69 μM), showed good to moderate urease inhibitory potential. © 2015, Chemical Society of Pakistan. All rights reserved.
publisher Chemical Society of Pakistan
issn 2535106
language English
format Article
accesstype
record_format scopus
collection Scopus
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