Synthesis of benzophenone hydrazone analogs and their DPPH radical scavenging and urease inhibitory activities
Benzophenone hydrazone analogs 1-25 were synthesized and evaluated for antioxidant (DPPH radical scavenging), and urease inhibitory activities. Out of twenty-five analogs, compounds 8, 23, and 1 showed potent free radical scavenging activities with IC50 values 19.45 ± 1.25, 21.72 ± 1.49, and 26.0 ±...
| Published in: | Journal of the Chemical Society of Pakistan |
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| Main Author: | |
| Format: | Article |
| Language: | English |
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Chemical Society of Pakistan
2015
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84937831128&partnerID=40&md5=310b2153b6efc997fe232f52ca8bd606 |
| Summary: | Benzophenone hydrazone analogs 1-25 were synthesized and evaluated for antioxidant (DPPH radical scavenging), and urease inhibitory activities. Out of twenty-five analogs, compounds 8, 23, and 1 showed potent free radical scavenging activities with IC50 values 19.45 ± 1.25, 21.72 ± 1.49, and 26.0 ± 0.52 μM, respectively, while compound 8 (IC50 = 36.36 ± 0.94 μM), and 15 (IC50 = 55.5 ± 0.69 μM), showed good to moderate urease inhibitory potential. © 2015, Chemical Society of Pakistan. All rights reserved. |
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| ISSN: | 2535106 |