Synthesis of 3,4,5-trihydroxybenzohydrazone and evaluation of their urease inhibition potential

QR Code

Synthesis of 3,4,5-trihydroxybenzohydrazone and evaluation of their urease inhibition potential

In the continuation of our work to synthesize enzyme inhibitors, we synthesized 3,4,5-trihydroxybenzohydrazones (1–19) from 3,4,5-trihydroxybenzohydrazide, which were obtained from methyl 3,4,5-trihydroxybenzoate by refluxing with hydrazine hydrate. All the synthesized compounds were characterized b...

Full description

Bibliographic Details
Published in:	Arabian Journal of Chemistry
Main Author:	Taha M.; Shah S.A.A.; Khan A.; Arshad F.; Ismail N.H.; Afifi M.; Imran S.; Choudhary M.I.
Format:	Article
Language:	English
Published:	Elsevier B.V. 2019
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84936883954&doi=10.1016%2fj.arabjc.2015.06.036&partnerID=40&md5=642ba72e72ec27c270f7001a0b710ff5

Similar Items

Synthesis crystal structure of 2-methoxybenzoylhydrazones and evaluation of their α-glucosidase and urease inhibition potential
by: Taha M.; Ismail N.H.; Baharudin M.S.; Lalani S.; Mehboob S.; Khan K.M.; Yousuf S.; Siddiqui S.; Rahim F.; Choudhary M.I.
Published: (2015)

Erratum: Synthesis crystal structure of 2-methoxybenzoylhydrazones and evaluation of their α-glucosidase and urease inhibition potential (Medicinal Chemistry Research (DOI 10.1007/s00044-014-1213-8))
by: Taha M.; Ismail N.H.; Baharudin M.S.; Lalani S.; Mehboob S.; Khan K.M.; Yousuf S.; Siddiqui S.; Rahim F.; Choudhary M.I.
Published: (2015)

Synthesis of novel derivatives of oxindole, their urease inhibition and molecular docking studies
by: Taha M.; Ismail N.H.; Khan A.; Shah S.A.A.; Anwar A.; Halim S.A.; Fatmi M.Q.; Imran S.; Rahim F.; Khan K.M.
Published: (2015)

Conventional versus microwave assisted synthesis, molecular docking and enzyme inhibitory activities of new 3,4,5-trisubstituted-1,2,4-triazole analogues
by: Virk N.A.; Rehman A.; Abbasi M.A.; Siddiqui S.Z.; Rashid U.; Iqbal J.; Saleem M.; Ashraf M.; Shahid W.; Shah S.A.A.
Published: (2018)

Synthesis, α-glucosidase inhibition and molecular docking study of coumarin based derivatives
by: Taha M.; Shah S.A.A.; Afifi M.; Imran S.; Sultan S.; Rahim F.; Khan K.M.
Published: (2018)

Synthesis of 2-acylated and sulfonated 4-hydroxycoumarins: In vitro urease inhibition and molecular docking studies
by: Rashid U.; Rahim F.; Taha M.; Arshad M.; Ullah H.; Mahmood T.; Ali M.
Published: (2016)

Xanthine oxidase inhibition by 5-aryledene N,N'-dimethylbarbituric acid derivatives
by: Khan K.M.; Khan M.; Karim A.; Taha M.; Ambreen N.; Gojayev A.; Perveen S.; Choudhary M.I.
Published: (2013)

Antiglycation and antioxidant potential of novel imidazo[4,5-b]pyridine benzohydrazones
by: Taha M.; Alkadi K.A.A.; Ismail N.H.; Imran S.; Adam A.; Kashif S.M.; Shah S.A.A.; Jamil W.; Sidiqqui S.; Khan K.M.
Published: (2019)

5-Bromo-2-aryl benzimidazole derivatives as non-cytotoxic potential dual inhibitors of α-glucosidase and urease enzymes
by: Arshad T.; Khan K.M.; Rasool N.; Salar U.; Hussain S.; Asghar H.; Ashraf M.; Wadood A.; Riaz M.; Perveen S.; Taha M.; Ismail N.H.
Published: (2017)

2-(2′-Pyridyl) benzimidazole derivatives and their urease inhibitory activity
by: Saify Z.S.; Kamil A.; Akhtar S.; Taha M.; Khan A.; Khan K.M.; Jahan S.; Rahim F.; Perveen S.; Choudhary M.I.
Published: (2014)

Synthesis and structure-activity relationship of thiobarbituric acid derivatives as potent inhibitors of urease
by: Khan K.M.; Rahim F.; Khan A.; Shabeer M.; Hussain S.; Rehman W.; Taha M.; Khan M.; Perveen S.; Choudhary M.I.
Published: (2014)

Synthesis of 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives and evaluation of their antiglycation potential
by: Taha M.; Ismail N.H.; Jamil W.; Imran S.; Rahim F.; Kashif S.M.; Zulkefeli M.
Published: (2016)

α-Glucosidase inhibition and docking studies of 5-deoxyflavonols and dihydroflavonols isolated from abutilon Pakistanicum
by: Hussain M.; Ahmed Z.; Khan S.N.; Shah S.A.A.; Razi R.; Imran S.; Khalid M.; Ali B.; Irshad M.B.; Nawaz F.; Chaudhry M.I.
Published: (2019)

Synthesis, in vitro urease inhibitory potential and molecular docking study of Benzimidazole analogues
by: Zaman K.; Rahim F.; Taha M.; Ullah H.; Wadood A.; Nawaz M.; Khan F.; Wahab Z.; Shah S.A.A.; Rehman A.U.; Kawde A.-N.; Gollapalli M.
Published: (2019)

Synthesis of benzophenone hydrazone analogs and their DPPH radical scavenging and urease inhibitory activities
by: Khan K.M.; Rahim F.; Khan A.; Ali S.; Taha M.; Saad S.M.; Khan M.; Najeebullah; Shaikh A.; Perveen S.; Choudhary M.I.
Published: (2015)

Synthesis, molecular docking and α-glucosidase inhibition of 5-aryl-2-(6′-nitrobenzofuran-2′-yl)-1,3,4-oxadiazoles
by: Taha M.; Ismail N.H.; Imran S.; Wadood A.; Rahim F.; Saad S.M.; Khan K.M.; Nasir A.
Published: (2016)

Synthesis, in vitro urease inhibitory potential and molecular docking study of benzofuran-based-thiazoldinone analogues
by: Taha M.; Rahim F.; Ullah H.; Wadood A.; Farooq R.K.; Shah S.A.A.; Nawaz M.; Zakaria Z.A.
Published: (2020)

Synthesis of 4-methoxybenzoylhydrazones and evaluation of their antiglycation activity
by: Taha M.; Naz H.; Rasheed S.; Ismail N.H.; Rahman A.A.; Yousuf S.; Choudhary M.I.
Published: (2014)

Bisindolylmethane thiosemicarbazides as potential inhibitors of urease: Synthesis and molecular modeling studies
by: Taha M.; Ullah H.; Al Muqarrabun L.M.R.; Khan M.N.; Rahim F.; Ahmat N.; Javid M.T.; Ali M.; Khan K.M.
Published: (2018)

4-[5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl]benzohydrazide
by: Taha M.; Ismail N.H.; Imran S.; Khan K.M.
Published: (2014)

Synthesis, In Vitro Enzymatic Inhibition, and Molecular Modeling of Novel Piperazine-Based Bis-Schiff Base Derivatives as Promising Anti-urease Agents
by: Masood N.; Hussain R.; Khan S.; Rahim F.; Mumtaz S.; Taha M.; Ur Rahman Abid O.; Iqbal T.; Adnan Ali Shah S.; Omar Al Wesabi E.; Magam S.M.
Published: (2024)

Synthesis, biological evaluation, and docking studies of novel thiourea derivatives of bisindolylmethane as carbonic anhydrase II inhibitor
by: Imran S.; Taha M.; Ismail N.H.; Fayyaz S.; Khan K.M.; Choudhary M.I.
Published: (2015)

Synthesis of 4-thiazolidinone analogs as potent in vitro anti-urease agents
by: Rahim F.; Zaman K.; Ullah H.; Taha M.; Wadood A.; Javed M.T.; Rehman W.; Ashraf M.; Uddin R.; Uddin I.; Asghar H.; Khan A.A.; Khan K.M.
Published: (2015)

Synthesis, In Vitro Enzymatic Inhibition, and Molecular Modeling of Novel Piperazine-Based Bis-Schiff Base Derivatives as Promising Anti-urease Agents
by: Masood, et al.
Published: (2024)

Synthesis of diindolylmethane (DIM) bearing thiadiazole derivatives as a potent urease inhibitor
by: Taha M.; Rahim F.; Khan A.A.; Anouar E.H.; Ahmed N.; Shah S.A.A.; Ibrahim M.; Zakari Z.A.
Published: (2020)

Design, synthesis, in vitro evaluation, molecular docking and ADME properties studies of hybrid bis-coumarin with thiadiazole as a new inhibitor of Urease
by: Alomari M.; Taha M.; Imran S.; Jamil W.; Selvaraj M.; Uddin N.; Rahim F.
Published: (2019)

Synthesis, in vitro and in silico studies of novel potent urease inhibitors: N-[4-({5-[(3-Un/substituted-anilino-3-oxopropyl)sulfanyl]-1,3,4-oxadiazol-2-yl}methyl)-1,3-thiazol-2-yl]benzamides
by: Abbasi M.A.; Hassan M.; Aziz-ur-Rehman; Siddiqui S.Z.; Raza H.; Shah S.A.A.; Seo S.-Y.
Published: (2018)

Synthesis, in vitro evaluation and molecular docking studies of hybrid 4-quinolinyl bearing 1,3,4-thiadiazole-2-amine as a new inhibitor of α-amylase and α-glucosidase
by: Taha M.; Khan A.A.; Rahim F.; Hayat S.; Imran S.; Iqbal N.; Uddin N.; Khan K.M.; Anouar E.H.; Farooq R.K.; Nawaz M.; Shah S.A.A.
Published: (2023)

Synthesis, spectral analysis and biological evaluation of 2-{[(morpholin-4-yl)ethyl]thio}-5-phenyl/aryl-1,3,4-oxadiazole derivatives
by: Aziz-Ur-Rehman; Khan S.G.; Naqvi S.A.R.; Ahmad M.; Akhtar N.; Bokhari T.H.; Irfan M.; Usman A.; Batool S.; Rasool S.; Shah S.A.A.; Shahid M.
Published: (2021)

Design, synthesis of triazole-based scaffolds, N-(substitutedphenyl)-2-(5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazol-3-ylthiol)acetamides: As potential anti-cholinesterase agents for neurodegenerative diseases
by: Siddiqui S.Z.; Arfan M.; Abbasi M.A.; Aziz-ur-Rehman; Shah S.A.A.; Parveen R.; Ashraf M.; Solangi M.; Hussain S.; Khan K.M.
Published: (2023)

Novel Bi-heterocycles as potent inhibitors of Urease and less cytotoxic agents: 3-({5-((2-amino-1,3-thiazol-4-yl)methyl)-1,3,4-oxadiazol-2-yl}sulfanyl)-N-(un/substituted-phenyl) propanamides
by: Abbasi M.A.; Ramzan M.S.; Aziz-Ur-Rehman; Siddiqui S.Z.; Hassan M.; Shah S.A.A.; Ashraf M.; Shahid M.; Seo S.-Y.
Published: (2020)

Synthesis of new urease enzyme inhibitors as antiulcer drug and computational study
by: Taha M.; Ismail S.; Imran S.; Almandil N.B.; Alomari M.; Rahim F.; Uddin N.; Hayat S.; Zaman K.; Ibrahim M.; Alghanem B.; Islam I.; Farooq R.K.; Boudjelal M.; Khan K.M.
Published: (2022)

Synthesis of potent urease inhibitors based on disulfide scaffold and their molecular docking studies
by: Taha M.; Ismail N.H.; Imran S.; Wadood A.; Rahim F.; Riaz M.
Published: (2015)

Synthesis, bacterial biofilm inhibition and hemolytic activity of 4-chloro-n-(dimethylphenyl)butamide regio-isomers
by: Abbasi M.A.; Hassan M.S.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.; Khan K.M.
Published: (2020)

Synthesis and in vitro study of benzofuran hydrazone derivatives as novel alpha-amylase inhibitor
by: Taha M.; Shah S.A.A.; Imran S.; Afifi M.; Chigurupati S.; Selvaraj M.; Rahim F.; Ullah H.; Zaman K.; Vijayabalan S.
Published: (2017)

Synthesis, molecular docking study and thymidine phosphorylase inhibitory activity of 3-formylcoumarin derivatives
by: Taha M.; Adnan Ali Shah S.; Afifi M.; Imran S.; Sultan S.; Rahim F.; Hadiani Ismail N.; Mohammed Khan K.
Published: (2018)

Synthesis, characterization, antibacterial, hemolytic and thrombolytic activity evaluation of 5-(3-chlorophenyl)-2-((N-(substituted)-2-acetamoyl)sulfanyl)-1,3,4-oxadiazole derivatives
by: Aziz-Ur-Rehman; Khan S.G.; Bokhari T.H.; Anjum F.; Akhter N.; Rasool S.; Ali Shah S.A.; Shahid M.; Arshad A.
Published: (2020)

In vitro antioxidant and in silico enzyme inhibition studies of Carissa carandas Linn.: potential ingredient for nutraceutical development
by: Zubair M.; Tousif M.I.; Riaz N.; Saleem M.; Nazir M.; Tauseef S.; Hassan A.; Shah S.A.A.; Zengin G.; Hashem A.; Kumar A.; Abd_Allah E.F.
Published: (2024)

Synthesis and β-glucuronidase inhibitory activity of 2-arylquinazolin-4(3H)-ones
by: Khan K.M.; Saad S.M.; Shaikh N.N.; Hussain S.; Fakhri M.I.; Perveen S.; Taha M.; Choudhary M.I.
Published: (2014)

Discovering biological efficacy of new thiadiazole as effective inhibitors of urease, glycation, and (DPPH) scavengers: Biochemical and in silico study
by: Taha M.; Imran S.; Rahim F.; Uddin N.; Iqbal N.; Khan K.M.; Farooq R.K.; Alomari M.; Islam I.; Algheribe S.
Published: (2023)