Synthesis, in vitro evaluation and molecular docking studies of thiazole derivatives as new inhibitors of α-glucosidase

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Synthesis, in vitro evaluation and molecular docking studies of thiazole derivatives as new inhibitors of α-glucosidase

A series of thiazole derivatives 1-21 were prepared, characterized by EI-MS and 1H NMR and evaluated for α-glucosidase inhibitory potential. All twenty one derivatives showed good α-glucosidase inhibitory activity with IC50 value ranging between 18.23 ± 0.03 and 424.41 ± 0.94 μM when compared with t...

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Bibliographic Details
Published in:	Bioorganic Chemistry
Main Author:	Rahim F.; Ullah H.; Javid M.T.; Wadood A.; Taha M.; Ashraf M.; Shaukat A.; Junaid M.; Hussain S.; Rehman W.; Mehmood R.; Sajid M.; Khan M.N.; Khan K.M.
Format:	Article
Language:	English
Published:	Academic Press Inc. 2015
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84935492350&doi=10.1016%2fj.bioorg.2015.06.006&partnerID=40&md5=28062b694b741d707e1fda11bd617d5d

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