Synthesis of benzimidazole derivatives as potent β-glucuronidase inhibitors

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Synthesis of benzimidazole derivatives as potent β-glucuronidase inhibitors

Twenty five 4, 6-dichlorobenzimidazole derivatives (1-25) have been synthesized and evaluated against β-glucuronidase inhibitory activity. The compounds which actively inhibit β-glucuronidase activity have IC50 values ranging between 4.48 and 46.12 μM and showing better than standard d-saccharic aci...

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Bibliographic Details
Published in:	Bioorganic Chemistry
Main Author:	Taha M.; Ismail N.H.; Imran S.; Selvaraj M.; Rashwan H.; Farhanah F.U.; Rahim F.; Kesavanarayanan K.S.; Ali M.
Format:	Article
Language:	English
Published:	Academic Press Inc. 2015
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84930958744&doi=10.1016%2fj.bioorg.2015.05.010&partnerID=40&md5=c5aa5ef1ca388142a22315a24df9e17f

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