Synthesis of benzimidazole derivatives as potent β-glucuronidase inhibitors
Twenty five 4, 6-dichlorobenzimidazole derivatives (1-25) have been synthesized and evaluated against β-glucuronidase inhibitory activity. The compounds which actively inhibit β-glucuronidase activity have IC50 values ranging between 4.48 and 46.12 μM and showing better than standard d-saccharic aci...
| Published in: | Bioorganic Chemistry |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Academic Press Inc.
2015
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84930958744&doi=10.1016%2fj.bioorg.2015.05.010&partnerID=40&md5=c5aa5ef1ca388142a22315a24df9e17f |