Synthetic indole Mannich bases: Their ability to modulate in vitro cellular immunity

Synthetic indole Mannich bases: Their ability to modulate in vitro cellular immunity

The synthetic indole Mannich bases 1-13 have been investigated for their ability to modulate immune responses measured in vitro. These activities were based on monitoring their affects on T-lymphocyte proliferation, reactive oxygen species (ROS), IL (interleukin)-2, IL-4, and nitric oxide production...

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Published in:Bioorganic Chemistry
Main Author: Mesaik M.A.; Khan K.M.; Rahim F.; Taha M.; Haider S.M.; Perveen S.; Khalid A.S.; Abdalla O.M.; Soomro S.; Voelter W.
Format: Article
Language:English
Published: Academic Press Inc. 2015
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84929625705&doi=10.1016%2fj.bioorg.2015.05.003&partnerID=40&md5=023d29260820d64c8fb0644fb0c650da
id 2-s2.0-84929625705
spelling 2-s2.0-84929625705
Mesaik M.A.; Khan K.M.; Rahim F.; Taha M.; Haider S.M.; Perveen S.; Khalid A.S.; Abdalla O.M.; Soomro S.; Voelter W.
Synthetic indole Mannich bases: Their ability to modulate in vitro cellular immunity
2015
Bioorganic Chemistry
60

10.1016/j.bioorg.2015.05.003
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84929625705&doi=10.1016%2fj.bioorg.2015.05.003&partnerID=40&md5=023d29260820d64c8fb0644fb0c650da
The synthetic indole Mannich bases 1-13 have been investigated for their ability to modulate immune responses measured in vitro. These activities were based on monitoring their affects on T-lymphocyte proliferation, reactive oxygen species (ROS), IL (interleukin)-2, IL-4, and nitric oxide production. Compound 5 was found to be the most potent immunomodulator in this context. Four of the synthesized compounds, 5, 11, 12, and 13, have significant potent inhibitory effects on T-cell proliferation, IL-4, and nitric oxide production. However, none of the thirteen indole compounds exerted any activity against ROS production. © 2015 Published by Elsevier Inc.
Academic Press Inc.
452068
English
Article
author Mesaik M.A.; Khan K.M.; Rahim F.; Taha M.; Haider S.M.; Perveen S.; Khalid A.S.; Abdalla O.M.; Soomro S.; Voelter W.
spellingShingle Mesaik M.A.; Khan K.M.; Rahim F.; Taha M.; Haider S.M.; Perveen S.; Khalid A.S.; Abdalla O.M.; Soomro S.; Voelter W.
Synthetic indole Mannich bases: Their ability to modulate in vitro cellular immunity
author_facet Mesaik M.A.; Khan K.M.; Rahim F.; Taha M.; Haider S.M.; Perveen S.; Khalid A.S.; Abdalla O.M.; Soomro S.; Voelter W.
author_sort Mesaik M.A.; Khan K.M.; Rahim F.; Taha M.; Haider S.M.; Perveen S.; Khalid A.S.; Abdalla O.M.; Soomro S.; Voelter W.
title Synthetic indole Mannich bases: Their ability to modulate in vitro cellular immunity
title_short Synthetic indole Mannich bases: Their ability to modulate in vitro cellular immunity
title_full Synthetic indole Mannich bases: Their ability to modulate in vitro cellular immunity
title_fullStr Synthetic indole Mannich bases: Their ability to modulate in vitro cellular immunity
title_full_unstemmed Synthetic indole Mannich bases: Their ability to modulate in vitro cellular immunity
title_sort Synthetic indole Mannich bases: Their ability to modulate in vitro cellular immunity
publishDate 2015
container_title Bioorganic Chemistry
container_volume 60
container_issue
doi_str_mv 10.1016/j.bioorg.2015.05.003
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-84929625705&doi=10.1016%2fj.bioorg.2015.05.003&partnerID=40&md5=023d29260820d64c8fb0644fb0c650da
description The synthetic indole Mannich bases 1-13 have been investigated for their ability to modulate immune responses measured in vitro. These activities were based on monitoring their affects on T-lymphocyte proliferation, reactive oxygen species (ROS), IL (interleukin)-2, IL-4, and nitric oxide production. Compound 5 was found to be the most potent immunomodulator in this context. Four of the synthesized compounds, 5, 11, 12, and 13, have significant potent inhibitory effects on T-cell proliferation, IL-4, and nitric oxide production. However, none of the thirteen indole compounds exerted any activity against ROS production. © 2015 Published by Elsevier Inc.
publisher Academic Press Inc.
issn 452068
language English
format Article
accesstype
record_format scopus
collection Scopus
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