Isatin based Schiff bases as inhibitors of α-glucosidase: Synthesis, characterization, in vitro evaluation and molecular docking studies

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Isatin based Schiff bases as inhibitors of α-glucosidase: Synthesis, characterization, in vitro evaluation and molecular docking studies

Isatin base Schiff bases (1-20) were synthesized, characterized by 1H NMR and EI/MS and evaluated for α-glucosidase inhibitory potential. Out of these twenty (20) compounds only six analogs showed potent α-glucosidase inhibitory potential with IC50 value ranging in between 2.2 ± 0.25 and 83.5 ± 1.0...

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Bibliographic Details
Published in:	Bioorganic Chemistry
Main Author:	Rahim F.; Malik F.; Ullah H.; Wadood A.; Khan F.; Javid M.T.; Taha M.; Rehman W.; Ur Rehman A.; Khan K.M.
Format:	Article
Language:	English
Published:	Academic Press Inc. 2015
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84928815461&doi=10.1016%2fj.bioorg.2015.03.005&partnerID=40&md5=113e06e633c17ccb7db89b098099d502

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