Orofacial pain of muscular origin is not associated with herpes virus-6 infection: A pilot study

Aims: To carry out a pilot study to test the hypothesis that human herpes virus-6 (HHV-6) infection or reactivation plays a role in the pathogenesis of temporomandibular disorders (TMD) of muscular origin (ie, localized myalgia). Methods: Sixteen patients with localized myalgia participated in this...

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Published in:Journal of Oral and Facial Pain and Headache
Main Author: Shoji Y.; Choo H.L.; Leong C.O.; Oo A.L.; Townsend G.
Format: Article
Language:English
Published: Quintessence Publishing Co. Inc. 2014
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84922217717&doi=10.11607%2fofph.1095&partnerID=40&md5=3014d271edb493d95dfd5ee80cec57e8
id 2-s2.0-84922217717
spelling 2-s2.0-84922217717
Shoji Y.; Choo H.L.; Leong C.O.; Oo A.L.; Townsend G.
Orofacial pain of muscular origin is not associated with herpes virus-6 infection: A pilot study
2014
Journal of Oral and Facial Pain and Headache
28
4
10.11607/ofph.1095
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84922217717&doi=10.11607%2fofph.1095&partnerID=40&md5=3014d271edb493d95dfd5ee80cec57e8
Aims: To carry out a pilot study to test the hypothesis that human herpes virus-6 (HHV-6) infection or reactivation plays a role in the pathogenesis of temporomandibular disorders (TMD) of muscular origin (ie, localized myalgia). Methods: Sixteen patients with localized myalgia participated in this pilot study. Thirty-six healthy individuals served as controls. The participants were examined clinically for the presence of the TMD according to the Research Diagnostic Criteria for TMD, and the salivary levels of HHV-6 were measured by quantitative polymerase chain reaction (qPCR). The Z test, Student t test, and Mann- Whitney U test were used as appropriate. Results: The results demonstrated that 77.8% of healthy individuals were HHV-6 positive, but a significantly lower proportion (43.8%) of the TMD patients with localized myalgia were positive for HHV-6 (P < .05, Fisher exact test). The levels of HHV-6B DNA were lower in the saliva of HHV-6-positive TMD patients with localized myalgia (median: 564 genome/mL; range: 184 to 5,835 genome/mL) than in that of healthy individuals (median: 1,081 genome/mL; range: 193 to 8,807 genome/mL), but the difference was not statistically significant (P > .05, Mann-Whitney U test). Conclusion: The results of this pilot study indicate that HHV-6 infection or reactivation does not appear to play a role in the pathogenesis of TMD reflecting a localized myalgia.
Quintessence Publishing Co. Inc.
23330384
English
Article

author Shoji Y.; Choo H.L.; Leong C.O.; Oo A.L.; Townsend G.
spellingShingle Shoji Y.; Choo H.L.; Leong C.O.; Oo A.L.; Townsend G.
Orofacial pain of muscular origin is not associated with herpes virus-6 infection: A pilot study
author_facet Shoji Y.; Choo H.L.; Leong C.O.; Oo A.L.; Townsend G.
author_sort Shoji Y.; Choo H.L.; Leong C.O.; Oo A.L.; Townsend G.
title Orofacial pain of muscular origin is not associated with herpes virus-6 infection: A pilot study
title_short Orofacial pain of muscular origin is not associated with herpes virus-6 infection: A pilot study
title_full Orofacial pain of muscular origin is not associated with herpes virus-6 infection: A pilot study
title_fullStr Orofacial pain of muscular origin is not associated with herpes virus-6 infection: A pilot study
title_full_unstemmed Orofacial pain of muscular origin is not associated with herpes virus-6 infection: A pilot study
title_sort Orofacial pain of muscular origin is not associated with herpes virus-6 infection: A pilot study
publishDate 2014
container_title Journal of Oral and Facial Pain and Headache
container_volume 28
container_issue 4
doi_str_mv 10.11607/ofph.1095
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-84922217717&doi=10.11607%2fofph.1095&partnerID=40&md5=3014d271edb493d95dfd5ee80cec57e8
description Aims: To carry out a pilot study to test the hypothesis that human herpes virus-6 (HHV-6) infection or reactivation plays a role in the pathogenesis of temporomandibular disorders (TMD) of muscular origin (ie, localized myalgia). Methods: Sixteen patients with localized myalgia participated in this pilot study. Thirty-six healthy individuals served as controls. The participants were examined clinically for the presence of the TMD according to the Research Diagnostic Criteria for TMD, and the salivary levels of HHV-6 were measured by quantitative polymerase chain reaction (qPCR). The Z test, Student t test, and Mann- Whitney U test were used as appropriate. Results: The results demonstrated that 77.8% of healthy individuals were HHV-6 positive, but a significantly lower proportion (43.8%) of the TMD patients with localized myalgia were positive for HHV-6 (P < .05, Fisher exact test). The levels of HHV-6B DNA were lower in the saliva of HHV-6-positive TMD patients with localized myalgia (median: 564 genome/mL; range: 184 to 5,835 genome/mL) than in that of healthy individuals (median: 1,081 genome/mL; range: 193 to 8,807 genome/mL), but the difference was not statistically significant (P > .05, Mann-Whitney U test). Conclusion: The results of this pilot study indicate that HHV-6 infection or reactivation does not appear to play a role in the pathogenesis of TMD reflecting a localized myalgia.
publisher Quintessence Publishing Co. Inc.
issn 23330384
language English
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