Bis(indolyl)methanes synthesis through sodium iodate and sodium hydrogen sulfite in water
An effective and eco-friendly method for the bis(indolyl)methanes synthesis has been developed. A successive methodology involving sodium iodate/sodium hydrogen sulfite catalyzed reaction of indole with many aldehydes gave the resultant bis-indol in good yield. This method offers synthetically inexp...
| Published in: | Journal of the Chemical Society of Pakistan |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Chemical Society of Pakistan
2015
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84920925932&partnerID=40&md5=ee98e21add15e44622aca39fdf0fd301 |
| Summary: | An effective and eco-friendly method for the bis(indolyl)methanes synthesis has been developed. A successive methodology involving sodium iodate/sodium hydrogen sulfite catalyzed reaction of indole with many aldehydes gave the resultant bis-indol in good yield. This method offers synthetically inexpensive alternate to the previously developed procedures for the bis-indol synthesis. The use of a low-cost and straightforwardly accessible catalyst, improved yields and a simple reaction process are the salient features of the current method. |
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| ISSN: | 2535106 |