Supramolecular phosphatases formed by the self-assembly of the bis(Zn2+-cyclen) complex, copper(II), and barbital derivatives in water
In our previous paper, we reported that a dimeric Zn2+ complex with a 2,2′-bipyridyl linker (Zn2L1), cyanuric acid (CA), and a Cu2+ ion automatically assemble in aqueous solution to form 4:4:4 complex 3, which selectively catalyzes the hydrolysis of mono(4-nitrophenyl)phosphate (MNP) at neutral pH....
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John Wiley and Sons Ltd
2014
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2-s2.0-84920710764 Zulkefeli M.; Hisamatsu Y.; Suzuki A.; Miyazawa Y.; Shiro M.; Aoki S. Supramolecular phosphatases formed by the self-assembly of the bis(Zn2+-cyclen) complex, copper(II), and barbital derivatives in water 2014 Chemistry - An Asian Journal 9 10 10.1002/asia.201402513 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84920710764&doi=10.1002%2fasia.201402513&partnerID=40&md5=869cbe4ffee981c16c29c7a0ebd5ab64 In our previous paper, we reported that a dimeric Zn2+ complex with a 2,2′-bipyridyl linker (Zn2L1), cyanuric acid (CA), and a Cu2+ ion automatically assemble in aqueous solution to form 4:4:4 complex 3, which selectively catalyzes the hydrolysis of mono(4-nitrophenyl)phosphate (MNP) at neutral pH. Herein, we report that the use of barbital (Bar) instead of CA for the self-assembly with Zn2L1 and Cu2+ induces 2:2:2 complexation of these components, and not the 4:4:4 complex, to form supramolecular complex 6a, the structure and equilibrium characteristics of which were studied by analytical and physical measurements. The finding show that 6a also accelerates the hydrolysis of MNP, similarly to 3. Moreover, inspired by the crystal structure of 6a, we prepared barbital units that contain functional groups on their side chains in an attempt to produce supramolecular phosphatases that possess functional groups near the Cu2(μ-OH)2 catalytic core so as to mimic the catalytic center of alkaline phosphatase (AP). © 2014 Wiley-VCH Verlag GmbH & Co. KGaA. John Wiley and Sons Ltd 18614728 English Article |
author |
Zulkefeli M.; Hisamatsu Y.; Suzuki A.; Miyazawa Y.; Shiro M.; Aoki S. |
spellingShingle |
Zulkefeli M.; Hisamatsu Y.; Suzuki A.; Miyazawa Y.; Shiro M.; Aoki S. Supramolecular phosphatases formed by the self-assembly of the bis(Zn2+-cyclen) complex, copper(II), and barbital derivatives in water |
author_facet |
Zulkefeli M.; Hisamatsu Y.; Suzuki A.; Miyazawa Y.; Shiro M.; Aoki S. |
author_sort |
Zulkefeli M.; Hisamatsu Y.; Suzuki A.; Miyazawa Y.; Shiro M.; Aoki S. |
title |
Supramolecular phosphatases formed by the self-assembly of the bis(Zn2+-cyclen) complex, copper(II), and barbital derivatives in water |
title_short |
Supramolecular phosphatases formed by the self-assembly of the bis(Zn2+-cyclen) complex, copper(II), and barbital derivatives in water |
title_full |
Supramolecular phosphatases formed by the self-assembly of the bis(Zn2+-cyclen) complex, copper(II), and barbital derivatives in water |
title_fullStr |
Supramolecular phosphatases formed by the self-assembly of the bis(Zn2+-cyclen) complex, copper(II), and barbital derivatives in water |
title_full_unstemmed |
Supramolecular phosphatases formed by the self-assembly of the bis(Zn2+-cyclen) complex, copper(II), and barbital derivatives in water |
title_sort |
Supramolecular phosphatases formed by the self-assembly of the bis(Zn2+-cyclen) complex, copper(II), and barbital derivatives in water |
publishDate |
2014 |
container_title |
Chemistry - An Asian Journal |
container_volume |
9 |
container_issue |
10 |
doi_str_mv |
10.1002/asia.201402513 |
url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84920710764&doi=10.1002%2fasia.201402513&partnerID=40&md5=869cbe4ffee981c16c29c7a0ebd5ab64 |
description |
In our previous paper, we reported that a dimeric Zn2+ complex with a 2,2′-bipyridyl linker (Zn2L1), cyanuric acid (CA), and a Cu2+ ion automatically assemble in aqueous solution to form 4:4:4 complex 3, which selectively catalyzes the hydrolysis of mono(4-nitrophenyl)phosphate (MNP) at neutral pH. Herein, we report that the use of barbital (Bar) instead of CA for the self-assembly with Zn2L1 and Cu2+ induces 2:2:2 complexation of these components, and not the 4:4:4 complex, to form supramolecular complex 6a, the structure and equilibrium characteristics of which were studied by analytical and physical measurements. The finding show that 6a also accelerates the hydrolysis of MNP, similarly to 3. Moreover, inspired by the crystal structure of 6a, we prepared barbital units that contain functional groups on their side chains in an attempt to produce supramolecular phosphatases that possess functional groups near the Cu2(μ-OH)2 catalytic core so as to mimic the catalytic center of alkaline phosphatase (AP). © 2014 Wiley-VCH Verlag GmbH & Co. KGaA. |
publisher |
John Wiley and Sons Ltd |
issn |
18614728 |
language |
English |
format |
Article |
accesstype |
|
record_format |
scopus |
collection |
Scopus |
_version_ |
1814778510479196160 |